A kasashe da dama a duniya cikin shekaru uku da rabi da suka gabata yanayin kiwon lafiya da na kudi na al'ummar kasar na yin koma-baya ta yadda ba a taba ganin irinsa ba a cikin shekarun da suka gabata. Binciken al'ada ya nuna karuwar adadin mace-mace masu yawa a cikin shekaru daban-daban da kuma hauhawar ruɓewar lafiyar mutane da iya aiki, musamman mata. Matakan kamuwa da cutar, maimaita alluran rigakafi da karuwar adadin mutane da suka hada da yara da mata masu juna biyu da ke fama da yunwa sun raunana garkuwar jikin mutane.
Rashin yanayin tsarin garkuwar jiki saboda rushewar microbiota na gut da kuma yawan bayyanar da damuwa na oxidative na iya tada hankali. S. ciwon huhu don canjawa daga ƙwayoyin cuta masu haɗaka zuwa ƙananan ƙwayoyin cuta masu dacewa da cutarwa wanda zai iya haifar da ciwon huhu, myocarditis, ciwon daji, cututtukan neurodegenerative, har ma da mutuwa kwatsam.
Don juyar da yanayin rashin lafiyar da ke gudana a cikin lafiya da tsawon rai duk wani tilastawa 'mai girma-daya-daidai-duk sashe' wanda zai iya haifar da rushewar tsarin garkuwar jiki yana buƙatar dakatar da shi. Ba tare da wani canji mai kyau ba a manufofin kiwon lafiyar jama'a na yanzu, ƙarin miliyoyin manya da yara za su mutu daga cutar huhu da cutar pneumococcal a cikin shekaru masu zuwa. Babu wani kamuwa da cuta da zai iya haifar da wannan adadin mace-mace.
Madadin haka, amintaccen, mai araha, da ingantaccen sa baki ta hanyar karin bitamin D mai fa'ida, sanannen ingantaccen maganin antioxidant da immunomodulator wanda zai iya hana kamuwa da cututtukan pneumococcal mai haɗari ana buƙatar gaggawa.
Gabaɗaya, hukumomin kiwon lafiyar jama'a da gwamnatoci za su iya saka hannun jari da kuma zabar abubuwan da ke hana rashin abinci mai gina jiki da matsanancin talauci. Ƙarfafa tsarin rigakafi na jama'a zai rage buƙatar kula da lafiya kuma yana ba da gudummawa ga duniya mai lafiya ga kowa.
Binciken Trend yana nuna raunin tsarin rigakafi na yawan jama'a
Bayanai a duk duniya sun nuna ci gaba da yawan mace-mace idan aka kwatanta da lokutan da aka riga aka kamu da cutar. A cewar OESO wanda ya kunshi adadin yawan mace-macen mazaunan biliyan 1.2 a shekarar 2022 ya kai miliyan 1.2. Rahotanni na Yuli 2023 sun nuna yawan mace-mace ya ci gaba da bambanta a cikin EU. Tsakanin su Sweden an sami mafi ƙarancin adadin mace-mace.
A karatun riga-kafi yana ba da shawarar cewa yawan mace-mace a cikin watanni tara na farko na shekarar 2022 ya karu fiye da mafi girman yawan allurar rigakafin 2021 da ke da alaƙa da mace-macen kowane wata a cikin 2022 da kashi 1,105. Binciken yawan mace-macen da aka yi a Japan da Jamus sun sami ƙaruwa sosai daga 5 da 10 bisa dari a cikin mace-mace a cikin 2021 da 2022 (2005-2022). Domin 96,5% mace-mace na wadanda ba cutar Covid-19 ba an gani a cikin allurar.
Binciken wucin gadi na tasirin rigakafin Covid-19 ta Cibiyar Kariya da Kula da Cututtuka ta Turai ta bayyana raguwar tasirin rigakafin ga duk rukunin shekaru bayan watanni 4 na allurar ƙarfafawa saboda ko dai tasirin raguwar rigakafi shi kaɗai ko don rigakafin kaddarorin tserewa na sabon bambance-bambancen Omicron. Bayanai na baya-bayan nan sun nuna cewa haɗarin kamuwa da cuta ƙara tare da adadin alluran alluran rigakafin Covid mRNA.
Ganin cewa an yi amfani da allurar rigakafin Covid-19 don kare mutanen da ke da raunin tsarin rigakafi don tsananin Covid-19, mutanen da ke da cututtuka daban-daban da magunguna daban-daban. amsa daban-daban, dangane da maganin da ake amfani da su da kuma nau'in cututtuka. Yawancin lokaci an shawarci mutanen da ke da raunin tsarin garkuwar jiki da su yawaita yin allura akai-akai don amsa da kyau. Kodayake, ra'ayoyin akan yawan ƙarfafawa allurar rigakafi da yadda ake ci gaba bayan kamuwa da cutar Covid-19 ya bambanta sosai a cikin Janairu 2022.
Hakanan, Hukumar Kula da Magunguna ta Turai ta yi gargadin cewa maimaita yawan allurai na Covid-19 na iya yin illa ga martanin rigakafin. Haka kuma, masu kara kuzari zai iya ba da gudummawa ga maye gurbi a kan rigakafin da aka samu tare da mafi girman watsawa, wanda zai haifar da dogon lokaci juriya na rigakafi da yuwuwar illolin cutarwa da mace-mace.
'Gashin rigakafin rigakafi' bayan maimaita allurar da alama yana ƙara dacewa da cutar ta Covid-19. Kodayake ci gaba da raguwa a cikin ƙwayoyin rigakafi bayan rigakafin Covid-19 galibi ana amfani dashi azaman hujja don maimaita rigakafin, tasirin rigakafi na maimaita rigakafin ya dogara da shekaru da martanin rigakafi na mutane. Adadin allurai iri ɗaya na iya gazawa ga wasu amma wuce gona da iri ga wasu. Kamar yadda rigakafin da aka samu daga kamuwa da cutar Covid shine a matsayin kariya kamar yadda allurar rigakafin rashin lafiya mai tsanani, damuwa don ƙarfafa rigakafi game da tasirin su, dorewarsu, da haɗarin haɗari ya kamata a ɗauka da mahimmanci.
Kusan shekaru biyu, labaran da aka yi bita na tsara kan yadda rigakafin Covid-19 zai iya Hallaka da rigakafi tsarin kuma yana haifar da cutarwa sau da yawa ana kiranta Alurar Rashin Immune Ciwo (VAIDS) an yi watsi da su.
Damuwa game da VAIDS yana tallafawa rahotanni daga Phinance Technologies, tare da bincike na yau da kullun kan yawan mace-mace, nakasassu, da asarar yawan aiki a cikin Burtaniya, Amurka, da Ostiraliya a cikin 2021 - 2023. Mutuwar 100k tana haɓaka ƙasa kafin 2020 kuma tana haɓaka tun daga 2020 tare da mutuwar 3 mafi girma / 100k Shekaru 2015-2019 tare da sigina masu mahimmancin ƙididdiga (al'amuran Swan baƙar fata). Haka kuma, haɓakar nakasa yana haɓaka sama da 15x fiye da mace-mace a cikin 44 daga PIP na Burtaniya don daban-daban. cututtuka na kullum duk da ciwon daji da kuma myocarditis. Kimanin mutane miliyan 2.6 ba su da aikin yi saboda rashin lafiya na dogon lokaci a Birtaniya. Ƙara yawan mace-mace akan ccututtuka na zuciya da jijiyoyin jini masu shekaru 15-44 sun karu da kashi 13 cikin 2020 a shekarar 30, kashi 2021 a shekarar 44 da kashi 2022 cikin XNUMX a shekarar XNUMX. Ba za a iya yin watsi da wadannan bayanai masu karfi ba kamar yadda shekara mai zuwa za a iya sa ran karin karuwa.
The rahoton lokaci on Epoch Times akan myocarditis da Covid-19 alluran rigakafin sun nuna yadda CDC ta rasa siginar aminci kuma ta ɓoye gargaɗi. An kara yawan karatun da aka yi bita a kan myocarditis da kuma pericarditis har ma Mutuwar Zuciya kwatsam bayan an buga allurar rigakafin Covid-19. Ko da kima na zuciya shekara guda daga baya yana nuna yuwuwar tasiri na dogon lokaci na Covid-19 mai alaƙa da myocarditis akan ƙarfin motsa jiki da ajiyar aikin zuciya yayin damuwa. Haɗari mafi girma ga myo / pericarditis An gano shari'o'in a cikin waɗanda suka karɓi rigakafin mRNA Covid-19 idan aka kwatanta da waɗanda ba a yi musu allurar ba a cikin rashin kamuwa da cutar ta SARS-CoV-2. Ƙananan asymptomatic myocardial kumburi zai iya zama gama gari fiye da yadda ake tsammani. Bugu da ƙari, kwanan nan an gano kasancewar allurar mRNA a cikin zuciya har zuwa kwanaki 30 daga allurar rigakafi.
Har ma ga yara shekaru 0-14 Ana lura da yawan mace-mace a cikin Burtaniya da ƙasashen EU daga rabin na biyu na 2021. Kuma Naomi Wolf kwanan nan ya ba da rahoton cewa mace-macen mata a Amurka ya karu sosai a cikin 2021. Kwanan nan bita ya nuna mummunan tasirin rigakafin Covid akan sakamakon ciki da aikin haila. Bayan allurar rigakafi bayyanar cututtuka na jijiyoyin jini ya nuna babban cikas tare da alamun Long Covid.
Yayin da aka kashe biliyoyin kudaden haraji na shekaru hudu da suka gabata da nufin kare al'umma daga mutuwa ko cututtuka, bayanan hukuma sun nuna M yana nuna rashin tasiri, unsafe, Har ma da cutarwa siyasa. Abin takaici, a cikin ƙasashe da yawa hukumomin jama'a da gwamnatoci sun fara ba da shawarar rigakafin haɓakar rigakafi (6th allura) ba tare da izini ba. Ko da binciken ƙungiyar ma'aikatan kiwon lafiya ya nuna karin rashin saboda illolin da aka samu bayan allura na biyu, ana shawartar mutane su sake shan wani abin kara kuzari. Bugu da ƙari, da sabon nau'in rigakafin Covid ba a gwada shi a cikin mutane ba.
Yiwuwar alaƙar maimaita alluran Covid-19 mRNA tare da raguwar yanayin lafiyar jama'a, iya aiki, samun kudin shiga, da tsawon rayuwa har yanzu Cibiyoyin Kiwon Lafiyar Jama'a ba su bincika ko kuma sanar da jama'a ba. Abin mamaki, Ingila Farashin JCVI ya ce kungiyoyin da ke cikin hadarin ne kawai da wadanda shekarunsu suka kai 65 zuwa sama ya kamata a ba su alluran rigakafin duk da fargabar da ake da su na daukar nauyin kiwon lafiya a wannan hunturu.
Ko da lokacin da a takarda A kan ƙwayoyin cuta na numfashi sun yarda cewa allurar rigakafi na yanzu ba za su iya karewa daga cututtuka da cututtuka masu tsanani ba, mura na gwamnati na duniya da kamfen na rigakafi na Covid-19 na kaka / lokacin hunturu na gaba, yayin da bayanan da aka samu kwanan nan daga CDC sun nuna yanzu. 77 kashi na marasa lafiya da ke asibiti a cikin 2020 ba su da Covid a matsayin dalili na farko.
Boyayyen rawar Streptococcus pneumoniae a cikin cututtuka na ƙwayoyin cuta na numfashi
A cikin mahallin cutar ƙwayar cuta ta numfashi, yana da mahimmanci a gane cewa bambanci tsakanin ƙwayoyin cuta da ƙwayoyin cuta ba a bayyana ba a cikin wallafe-wallafe. A lokacin cutar ta Covid-19 Cutar Cutar Cutar Cutar Cutar Cutar Cutar Cutar Cutar (ARDS) an gabatar da ita bisa kuskure azaman sabuwar cuta. Tsawon shekaru ARDS ko guguwar cytokine an san shi da haɗarin haɗari ga mutanen da ke da raunin tsarin rigakafi, musamman a lokutan sanyi. A lokacin kamuwa da kwayar cutar kwayar cuta daidaituwa tare da sauran pathogens, musamman tare da Streptococcus pneumoniae an sha ba da rahoto akai-akai.
Ciwon huhu cututtuka kasance a babban dalili na ciwon huhu da ke da alaƙa da mura da mutuwa tsakanin sojoji da fararen hula a cikin bala'in 1918. Kashi XNUMX cikin XNUMX na ruwan majinyata na masu fama da ciwon huhu suna haifar da ƙwayoyin cuta.
Hakanan a lokacin cutar ta H1N1 2009 ciwon pneumococcal an gano shi a matsayin mafi yawan sanadin mutuwa tare da kashi 30 cikin 50 na marasa lafiya ba tare da alamun cutar huhu ba kuma kashi 2 kawai za a iya gano su tare da gwajin antigen na fitsari. Pneumococcal marasa lafiya da suka kamu da cutar sun nuna tsananin cutar tare da ƙarancin jikewar OXNUMX, mafi girma m lokaci serum matakan, babban barkwanci IgG4 subclass antibodies da yawan shigar da su zuwa Rukunin Kulawa na Tsanani (ICU) yana nuna haɗarin mace-mace. Kashi 29 cikin 100 na marasa lafiyar da suka mutu sakamakon kamuwa da cutar H1N1 mura yana da shaidar kamuwa da cutar kwayan cuta tare da pneumococci galibi nau'ikan da ba sa cikin maganin pneumococcal conjugate.
Abin takaici, daga rabin na biyu na karatun 2021 a cikin UK, Switzerland, da Jamus ya ba da rahoton sake bullar cutar huhu ta Community Acquired Pneumonia (CAP) ta S. Pneumoniae a cikin yara 'yan kasa da shekaru 15 da tsofaffi, tare da mafi girma Adadin rikice-rikice kamar yadda aka ruwaito na mura, kuma idan aka kwatanta da lokacin farko a cikin annoba da matakan riga-kafi duka a cikin Covid-19 da marasa lafiya na CAP na Covid-19. Wannan na iya nuna haɓakar cututtukan pneumococcal a duk rukunin shekaru yayin da daidaituwa tare da wasu ƙwayoyin cuta marasa Covid-19 ba su canza ba. Lokacin viral da S. ciwon huhu cututtuka suna faruwa tare, cututtuka suna kama da suna da alaƙa da tsananin COVID-19 da kuma mafi ƙarancin sakamako.
A cikin ƙasashe da yawa rigakafin pneumococcal conjugate (PCV) wani bangare ne na shirye-shiryen rigakafin gwamnati ga yara ƙanana da tsofaffi. Abin takaici, tasirin maganin rigakafin cututtukan pneumococcal na biyu ya rage rigima. Ragowar cuta wanda ke haifar da nau'in serotypes na alurar riga kafi da nau'in serotypes marasa alurar riga kafi sun kasance masu mahimmanci. Tasiri ya bambanta ta hanyar serotype da alluran rigakafi kuma an lura da tasirin PCV13 yana raguwa tare da lokaci bayan haɓakar rigakafin.
Bugu da ƙari, yawan adadin lokuta tare da abubuwan haɗari masu haɗari (cututtukan huhu na yau da kullum, ciwon daji, cututtukan zuciya. ea) ya karu da kashi 50 cikin dari a ƙarshen PCV13. Magungunan pneumococcal na yanzu suna bayarwa bai cika ba kariya daga kamuwa da cutar pneumococcal (IPD). Yawancin bambance-bambancen ɗari na capsular Arotypes fuskantar ci gaba da rigakafin kwastomomi da kuma maganin gina jiki mai nasara har yanzu ba su samu ba tukuna. Haɓaka matakan juriya na ƙwayoyin cuta suna da matsala masu tasiri masu tasiri.
Likitoci suna buƙatar samun ƙarin wayar da kan jama'a game da tsabar kuɗi ko kamuwa da cututtukan ƙwayoyin cuta tare da pneumococci, musamman kamar yadda CAP ko IPD na iya ci gaba da ƙaruwa. Rashin ƙima na pneumococcal CAP na iya faruwa saboda sau da yawa ana amfani da ƙarancin hankali na daidaitattun hanyoyin al'adun kulawa maimakon ingantacciyar gwajin antigen na fitsari.
Muhimmancin kamuwa da cutar huhu na huhu a matsayin mai ba da gudummawa ga mutuwa a cikin marasa lafiya tare da Covid-19 ya kasance. mara daraja ya zuwa yanzu. Wani bincike da aka buga a watan Mayu 2023 ya gano cewa ciwon huhu da ba ya warwarewa shine babban direba a cikin marasa lafiya da Covid-19. Cututtukan kwayoyin cuta na iya ma wuce adadin mutuwa daga kamuwa da kwayar cutar da kanta. Binciken ya nuna mahimmancin yin rigakafi da nema da mugun nufi na biyu kwayan ciwon huhu a cikin marasa lafiya masu fama da matsanancin ciwon huhu ciki har da Covid-19. Bayan watanni shida kashi 60 na marasa lafiya da ke asibiti sun nuna rashin daidaituwa a cikin gabobin da yawa, musamman kwakwalwa da huhu da kuma yawan masu alaƙa da zuciya hadari ciki har da bugun zuciya da ba daidai ba, bugun zuciya, da bugun jini. A cikin autopsy yana nazarin kewayon abubuwan da ba su da kyau, musamman ta yadda ƙwayoyin zuciya ke sarrafa calcium.
Dogon alamun Covid, kodayake har yanzu ma'ana mara kyau, ana iya danganta shi da a S. ciwon huhu kamuwa da cuta. Dogon lokaci abin rufe fuska zai iya haifar da overgrowth na S. ciwon huhu, wanda shine Kwayar cutar anaerobic tare da karuwar damar girma a cikin low O2 / CO2 arziki yanayi.
Gabaɗaya yana da mahimmanci a tuna cewa sabon bincike mai ƙima ya sami a ƙasa da ƙasa Adadin Mutuwar Kamuwa da Kamuwa kafin rigakafin cutar Covid-19 (0.03 - 0.07 bisa dari) a cikin yawan mutanen da ba su da girma a duniya fiye da yadda aka ba da shawara a baya. An lura da bambance-bambance masu girma tsakanin ƙasashe kuma suna iya nuna bambance-bambance a cikin cututtuka da sauran abubuwa. Da alama 'Babban barazanar Kiwon Lafiyar Jama'a ba kwayar cuta ba ce amma a raunana tsarin rigakafi. '
Dama don halayen cutarwa na Streptococcus pneumoniae a cikin raunin tsarin rigakafi
Matsayin da zai yiwu na watsawa Streptococcus pneumoniae girma dangane da mutuwar kwatsam, myocarditis, pericarditis, matsalolin fata, cututtukan autoimmune, da ciwon daji an bayyana su. Alamun asibiti, alamu, da binciken binciken jiki kaɗai iya ba bambanta S. ciwon huhu cuta daga cututtuka da wasu kwayoyin cuta ke haifarwa. Mazauni na kowa a cikin sashin numfashi na sama yawanci asymptomatic ne a cikin mutane masu lafiya. Ana samun jigilar kaya mafi girma a lokacin lokutan hunturu kuma sau da yawa a cikin cunkoson jama'a kamar kula da yara. Yayin da gabaɗayan harin pneumococcus yayi ƙasa, shine babban dalilin mutuwar masu kamuwa da cuta a duniya.
Ciwon cututtuka na faruwa da farko a cikin manya da ƙanana yayin da tsarin garkuwar jikinsu ba shi da haɓaka ko raguwa, bi da bi. A kowace shekara yara miliyan 12 na asibiti ciwon huhu mai tsanani bukatar gaggawa Oxygen magani don tsira. Ciwon huhu ya fi mayar da hankali hanawa da yaran da aka ware masu a talakawa mai gina jiki matsayi da raunin tsarin rigakafi. Akalla yaro daya ya mutu daga ciwon huhu kowane 39 seconds, wanda shine 800,000 a kowace shekara kuma ya fi yawan mace-mace fiye da kowace cuta a duniya. Kwatsam mutuwa a cikin jariri yana da alaƙa da cututtukan ƙwayoyin cuta. A nazari na ainihi an lura da alaƙar amsa kashi kwatsam mutuwar bazata da matsayin zamantakewa.
Abin takaici, rashin abinci mai gina jiki da kuma barazana of yunwa duniya yana tashi. Wani rahoton Majalisar Dinkin Duniya na baya-bayan nan game da tasirin cutar ta Covid-19 kai tsaye da kai tsaye ya ce ta kashe 228,000 yara a Kudancin Asiya da kuma karuwar fiye da kashi 20 cikin dari na mace-macen mata masu juna biyu.
Musamman tsofaffi da mutanen da ba su da rigakafi suna cikin haɗarin haɓaka cutar Pneumococcal Invasive Pneumococcal Disease (IPD), lokacin da ƙwayoyin cuta ke yaduwa daga nasopharynx zuwa wasu sassan jiki waɗanda suka haɗa da huhu, jini, da ƙwaƙwalwa. Da zarar a cikin jini pneumococci yana yaduwa zuwa gabobin da yawa inda kwayoyin zasu iya ɗaure.
Yayin da aka rubuta da yawa akan ciwon huhu na pneumococcal, binciken da aka yi kwanan nan ya nuna cewa S. Pneumoniae yana iya mamayewa myocardium kuma kashe cardiomyocytes. Ɗaya daga cikin mutane biyar masu fama da ciwon huhu a asibiti suna fama da rikice-rikice na zuciya kuma ga waɗanda ke fama da cutar bakteriya na pneumococcal mummunan abubuwan da ke faruwa na zuciya a cikin kwanciyar hankali abu ne mai haɗari har zuwa shekaru goma. Ma'amala tsakanin pneumococcus da zuciya shine fili mai tasowa.
Abubuwan da aka gano na virulence na pneumococcus wanda ke daidaita mafi girman kumburi da cytotoxicity sune bangon cell na pneumococcal, pneumolysin, hydrogen peroxide, da wasu samfurori masu ɓoye kamar peptidoglycan. Bangon tantanin halitta na pneumococcus yana hanawa don raunin zuciya. Pneumococcus toxin, pneumolysin, yana da ma'amala da yawa tare da mai watsa shiri wanda ke haifar da yaduwar cututtuka, ƙumburi mai tsanani, lalacewa mai yawa, da necrosis, yana rage aikin ƙwayoyin cuta. kwayoyin mast da damar da kwayoyin cuta ke ratsawa cikin jini.
Pneumolysin yana rushe siginar Ca2+ saboda samuwar pore ko da ba a kashe kwayoyin halitta nan da nan ba. Sakamakon hydrogen peroxide yana ba da gudummawa ga lalacewar mitochondrial na neurons da lalacewar zuciya. Za a iya samun hypoxia da hypotension tare da arrhythmia, ciwon zuciya na zuciya, myocarditis, pericarditis, da ciwon zuciya. Rikicin zuciya na iya faruwa saboda rashin ƙarancin iskar oxygen a lokacin ƙara yawan buƙatun zuciya da/ko saboda abubuwan da ba a yi niyya ba na ƙwayoyin cuta ko wasu magunguna.
Bacteremia na pneumococcal tare da kamuwa da cuta na metastatic da ciwon sankarau yana da alhakin mutuwa mai mahimmanci, musamman a cikin tsofaffi inda adadin zai iya kaiwa kashi 60 da kashi 80 bi da bi. Ana kuma san ƙwayoyin ƙwayoyin cuta a matsayin mai ba da gudummawa ga ƙarshen mataki ƙwayar koda a cikin yara da manya.
Mutanen da suka tsira daga cutar sankarau na pneumococcal sau da yawa suna fuskantar ci gaban jijiya na dindindin tare da lahani a cikin ƙwaƙwalwar ajiya da koyo saboda lalacewar neuronal ta pneumolysin da hydrogen. Idan pneumococcus ya shiga cikin kunne na tsakiya, pneumolysin yana ba da gudummawa sosai ga lalacewar cochlear da asarar ji. Kayayyakin ƙwayoyin cuta da aka ci karo da juna yayin daukar ciki na iya haɗawa da rashin fahimta a cikin yara.
Diversity gut microbiota mai kariya a cikin cututtuka da illar maganin alurar riga kafi
Tasirin microbiota na gut akan raguwar ƙarfin phagocytose da kashe ta alveolar macrophages na S. ciwon huhu an nuna shi a cikin binciken tare da microbiota depleted mice. Sakamakon binciken yana tallafawa aikin kariya na microbiota na gut akan gazawar gabobin yayin S pneumoniae haifar da sepsis. Alveolar macrophages ana tsammanin shine layin farko na kariya idan cutar ta mamaye huhu. Gut microbiota an nuna su daidaita garkuwar jiki da kamuwa da cutar ta sama ta numfashi
tare da cutar mura A. Matsayin microbiota na gut ya zama ma fi bayyana ta a Rahoton wanda ya bayyana nasarar magani tare da lactobacillus rhamnosus a cikin majinyata marasa lafiya da ke da alaƙa da ciwon huhu. Prophylaxis probiotic Hakanan yana da tasiri don hana ciwon huhu mai alaƙa da iska a cikin yara akan iskar injin.
Manyan al'ummomi na ƙwayoyin cuta na hanji ba wai kawai suna ba da gudummawa ga tsaro na gida daga kamuwa da cuta ba amma har ma suna daidaita martani a rukunin yanar gizo. Mice sun ƙare tare da microbiota kafin kamuwa da cuta S Pneumoniae ya nuna haɓakar hanta da raunin hanta. Bambanci a cikin microbiota abun da ke ciki A cikin na sama na numfashi tsakanin matasa da tsofaffi mice sun nuna karin bambance a cikin mice mice da kuma mafi sauri ga tushen tushe.
Haɗarin cutar pneumococcal mai haɗari ya fi girma ga marasa lafiya tare da cututtukan hanji mai kumburi ko wasu cututtuka da / ko amfani da yawa. magunguna cewa daidaitawa microbiota na ciki. A ciki mazan marasa lafiya na asibiti polypharmacy amma ba multimorbidity da frailty aka muhimmanci hade da gut dysbiosis. Tsananin dysbiosis ya iya yin hasashen mutuwa sosai bayan bin shekaru biyu. Wani bincike na tsawon lokaci na Ingilishi akan tsufa ya gano cewa tsofaffi tare da polypharmacy sun kasance cikin haɗari mafi girma na duk- sanadin mace-mace da mace-mace saboda cututtukan zuciya idan aka kwatanta da waɗanda ba su sha magani ba.
Nazarin kwanan nan ya nuna cewa dysbiosis na gut microbiota ana tsammanin shine dalilin mafi yawan cututtuka na zuciya da jijiyoyin jini, gami da cututtukan zuciya, hauhawar jini, arrhythmias, gazawar zuciya, da mutuwar zuciya kwatsam. Gut microbiota dysbiosis na iya haifar da amsa mai kumburi kuma yana shafar metabolism na kwayoyin halitta, wanda ke haifar da kumburi na tsarin da kuma rashin aikin endothelial. Wadannan canje-canje suna inganta ci gaban plaques na arterosclerotic kuma suna ƙara haɗarin thrombosis da abubuwan da ke faruwa na zuciya.
Rage bambance-bambancen halittu na gut microbiota a cikin jinsin halittu bifidobacteria ana lura da cututtukan hanji mai kumburi, kiba, cututtukan jijiyoyin jiki C. Wahala kamuwa da cuta, kuma kwanan nan mai tsanani Covid-19 kamuwa da cuta (ARDS). Marasa lafiya masu tsananin kamuwa da cutar SARS-CoV-2 suna da mahimmanci ƙarancin ƙwayar cuta tare da ƙananan yawa na Bifidobacterium da kuma Faecalibacterium kuma ya karu da yawa Bacteroidetes idan aka kwatanta da waɗanda ke da alamun haske.
An lura da haɗin kai kai tsaye tsakanin tsananin cutar Covid-19 da yawan Bacteroides. Wata babbar ƙungiya daga Amurka ta nuna hakan alamun narkewa An danganta su da marasa lafiya waɗanda ke nuna haɗarin kashi 70 na haɗarin gwaji ga SARS-CoV-2. Marasa lafiya tare da bayyanar GI kamar zawo sun kasance suna da alaƙa da tsawon lokacin cutar.
Bayanan farko sun nuna a m lalacewa zuwa ga microbiome gut tare da raguwa a ciki Bifidobacterium bin manzo RNA SARS-Cov-2 rigakafin. Rashin raguwa Bifidobacterium Bayan allurar rigakafin zai iya bayyana haɗarin da ke da girma ga a SARS-CoV-2 kamuwa da cuta bayan kowace allurar ƙarar mRNA. Analysis na Gidajen jinya na Amurka bayanai sun tabbatar da allurar rigakafin ya sa tsofaffi su mutu. Kwanan nan binciken tare da rigakafin BNT162b2 Covid a cikin yara an lura da canje-canjen martanin cytokine ga ƙwayoyin cuta masu kama da juna waɗanda zasu iya dagewa har zuwa watanni shida bayan rigakafin. Duk da haka, ba a bayyana ko waɗannan canje-canjen suna ba da kariya daga wasu cututtuka masu yaduwa ba.
Bincike ya nuna akwai a dangantakar bidirectional tsakanin gut microbiota da allurar Covid-19 da bambance-bambancen abubuwan microbiota ko dai suna haɓaka ko rage ingancin maganin. Abin takaici, lambobin UK na baya-bayan nan sun nuna cewa kashi 96.5 na yawan mace-mace sun faru a ciki alurar riga kafi mutane.
Rashin tsaro da abinci tamowa ana iya danganta shi da rashin girma na microbiota da/ko dysbiosis. Matsayin abinci mai gina jiki na iya shafar ingancin rigakafin Covid-19 ta hanyar daidaita yanayin rigakafi da tsarin da kuma rinjayar kumburi da damuwa na oxidative. Tare da mutane da yawa suna fuskantar a raunana tsarin garkuwar jiki, rushewar microbiota, da kuma ƙara yawan damuwa na oxyidative duk wani sa hannun da ba a yi la'akari da shi ba zai iya zama m ta hanyar harin guba na ƙarshe. Streptococcus pneumoniae akan garkuwar jiki.
A barazana matsalar rashin abinci a duniya saboda yaki da manufofin sauyin yanayi za su kara hadarin kamuwa da cututtuka masu tsanani da na yau da kullum. A lokacin pandemic yawan mutane da yara in matsanancin talauci ya tashi daga miliyan 70 zuwa miliyan 700. Haka kuma, rugujewar tsarin kula da lafiya ba zai iya rufe a bukatar don ƙarin kulawa da hauhawar adadin cututtuka da mace-mace.
Ci gaba da manufofin iri ɗaya zai sanya Majalisar Dinkin Duniya Shekaru Goma don Tsufa Lafiya 2020-2030 da kuma Yunwar Zero a cikin 2030 a farce kuma zai kara yawan rashin yarda da jama'a.
Bukatar gaggawa ga yawan jama'a mai fa'ida mai inganci mai inganci
A farkon barkewar cutar wallafe-wallafen kimiyya game da tasirin kariya na Vitamin D3 don rigakafin cututtukan ciwon huhu na yanayi da Ciwon Haɗaɗɗen Matsalolin numfashi ba a yi watsi da su ba kuma yawancin likitocin kiwon lafiya, masana kimiyya, masana, da 'yan siyasa da yawa sun yi jayayya da hujjar cewa. karin bincike za a buƙaci kafin gabaɗaya shawarwari za a iya yi. Duk da haka, kudin-tasiri Binciken cutarwa ya nuna ko da ƙaramin raguwar kamuwa da cuta zai iya tabbatar irin wannan shisshigi.
Bayanai daga Isra'ila, Spain, da Belgium sun nuna cewa ƙananan matakan bitamin D plasma 25 (OH) D suna da alamun haɗari mai zaman kansa na kamuwa da cuta na Covid-19, kuma mutuwar asibiti. Marasa lafiya da ke da rashi bitamin D sun fi yawan adadin abubuwan da aka tashe don cututtuka na zuciya da jijiyoyin jini.
Rashin bitamin D tare da maida hankali na 25 (OH) D da ke ƙasa <30 nmol/l yakamata ya kasance. kauce masa duk inda zai yiwu yayin da yake ƙara haɗarin haɗari yawan mace-mace, cututtuka, da cututtuka da yawa na yau da kullum watau ciwon huhu, sepsis, cututtukan zuciya, ciwon daji, ciwon sukari, tsoka, da lafiyar kashi. A wasu ƙasashe kusan kashi 80 na mutane suna fama da rashin bitamin D. Kusan mutane miliyan 66 a cikin EU suna nuna matakan bitamin D <50 nmol/l. Hypovitaminosis bitamin D yana lalata ayyukan mitochondrial kuma yana haɓaka danniya na oxidative da kumburin tsarin. An danganta rashi na bitamin D tare da dysbiosis na gut da kumburi kuma yana hade da muni sakamako na cututtuka. A tasirin synergistic of bitamin D3 da kuma Bifidobacterium an nuna a rage tsanani kwayar cuta da kuma kwayar cututtuka ta hanyar danne martani na kumburi da kuma toshe fassarar kwayoyin cuta.
Abin takaici, har ya zuwa yanzu babu abin da ya canza don kare al'ummar duniya daga rashi na bitamin D duk da ra'ayin cewa bitamin D yana da tarin yawa. immunomodulatory effects wanda zai iya zama mai fa'ida a cikin mahallin Covid-19 da ƙananan matakan bitamin D na iya haifar da tabarbarewar tasirin maganin ƙwayoyin cuta. Rashin bitamin D yana haifar da lalacewa yara zuwa cututtuka na numfashi.
Recent karatu ya nuna muhimmiyar rawar bitamin D sama da 50 nmol/l a kowane lokaci a shekara don kariya daga ciwon huhu ko ARDS da rigakafin asibiti, tare da kariya mafi kyau fiye da rigakafin Covid-19 ko allurar rigakafin mura kuma tare da ƙarancin illa. Matsayin kariya na bitamin D kari a cikin tsarin marasa lafiya tare da Covid-19 an nuna. Kariyar bitamin D da aka ba a kulawa ta yau da kullun azaman antioxidant da immunomodulator na iya tabbatar da tsaka-tsakin tsaka-tsaki mai sauƙi don gyara wani muhimmin abu mai haɗari ga tsarin garkuwar jiki, yana da fa'ida wajen haɓaka juriya ga cututtukan cututtukan numfashi gaba ɗaya. S. ciwon huhu, da/ko bambance-bambancen ƙwayoyin cuta na SARS-CoV-2 da/ko pathogen X.
A cikin fuskantar sabbin lokutan hunturu tare da ƙarin haɗari ga ARDS da a rugujewar tsarin kiwon lafiya, wani dabarun zuba jari da goyon baya a cikin lafiya na 'yan ƙasa kowane lokaci a shekara tare da matakan kariya na bitamin D matakan jini (aƙalla 50-100 nmol/l) amintaccen, mai araha, kuma saka hannun jari mai tsada. Wannan zai zama hanya mafi aminci da inganci don ba da gudummawa ga duniya mai tsufa mai lafiya, yunwar yunwa da rage ciwon huhu.
-
Carla Peeters ita ce ta kafa kuma darektan gudanarwa na COBALA Kyakkyawan Kulawa yana jin daɗi. Ita ce Shugaba na wucin gadi kuma mai ba da shawara kan dabarun don ƙarin lafiya da iya aiki a wurin aiki. Gudunmawarta ta mayar da hankali kan ƙirƙirar ƙungiyoyi masu lafiya, jagora zuwa ingantacciyar kulawa da jiyya masu tsada waɗanda ke haɗa abinci mai gina jiki da salon rayuwa a cikin magani. Ta samu digirin digirgir a fannin ilmin rigakafi daga sashen likitanci na Utrecht, ta karanci Kimiyyar Halittu a Jami’ar Wageningen da Bincike, sannan ta yi kwas na tsawon shekaru hudu a fannin Ilimin Kimiyyar Kimiyyar Halittu tare da kware a kan binciken dakin gwaje-gwaje na likitanci da bincike. Ta bi shirye-shiryen zartarwa a Makarantar Kasuwancin London, INSEAD da Makarantar Kasuwancin Nyenrode.
Duba dukkan posts
