Idan ba ku sani ba, MedPage tallace-tallace ne na masana'antar Pharmaceutical (ma'ana: Farfaganda) aiki aikawa a matsayin ainihin tushen gaskiyar likita.
A ranar 05 ga Janairu, 2024, wannan tashar Propaganda ta Pharma ta buga wata hira ta bidiyo da Dr. Paul Offit, kwararren likitan ilimin yara kuma shill alluran rigakafi, wanda a ciki ya bayyana jerin karairayi na ci gaba da iskar gas da karya wanda shi da Dr. Peter Marks (FDA/CBER) suka shahara da su.
Paul Offit Debunks Gargadin Babban Likitan Likita na Florida na Anti-Vax
- "Yana da wuya a yarda cewa da gaske Dr. Ladapo ya fitar da wannan sanarwa," in ji kwararre kan rigakafin
Bari mu dubi rubutun wannan jerin labaran karya.
Da farko, farawa da taken, shin Paul Offit da gaske kwararre ne na rigakafin? Menene gudunmawarsa a zahiri? To, ya bayyana kansa a matsayin wanda ya kirkiro rigakafin rotavirus mai lasisi (ɗaya daga cikin mutane da yawa, kuma ba na farko ba), kuma ya karɓi manyan sarakuna daga wannan. Ya kamata in ce a halin yanzu mai lasisin rigakafin rotavirus, saboda akwai riga-kafin rotavirus (RotaShield - Wyeth) wanda ke da alaƙa da matakin rashin haƙuri na rashin lafiya na asibiti da ake kira "intussusception."
Idan kun san dawakai, zaku iya tunanin intussusception kamar irin colic, amma galibi yana faruwa a cikin yara. Hakazalika, intussusception wani yanayi ne wanda wani sashe na hanji “telescopes” a cikin wani, yana haifar da toshewar hanji (toshewa). Don wasu dalilai, allurar rigakafin rotavirus suna da alaƙa da intussusception. Yana iya zama barazana ga rayuwa. Alurar rigakafin rotavirus da aka ba da lasisi a baya yana da ɗan ƙaramin ƙimar intussusception fiye da na yanzu da ke da alaƙa da Dr. Paul Offit (da Dr. H. Fred Clark, babban jami'in masu binciken biyu).
Wannan makala ta yi cikakken bayani game da abubuwan da suka shafi janyewar RotaShield, gami da rawar Offit lokacin shiga cikin Kwamitin Ba da Shawarwari kan Ayyukan rigakafi a CDC. Ainihin, ana buƙatar duk yaran Amurka su ɗauki ko dai maganin rigakafin Offit ko wani samfurin ƙwayoyin cuta mai kama da juna. A cewar CDC:
Hakanan akwai ƙaramin haɗarin kamuwa da kamuwa da cuta daga allurar rotavirus, yawanci a cikin mako guda bayan kashi na farko ko na biyu. An kiyasta wannan ƙarin haɗarin zai kasance daga kusan 1 cikin 20,000 zuwa 1 cikin jarirai 100,000 na Amurka waɗanda ke samun rigakafin rotavirus.
Akwai kimanin haihuwa miliyan 3.66 a kowace shekara a cikin Amurka, don haka yana nufin tsakanin 36 zuwa 180 lokuta na barazanar kamuwa da rayuwa a cikin Amurka a kowace shekara saboda umarnin sarrafa wannan samfurin.
Dr. Offit ne suka kirkiro samfurin rigakafin rotavirus na Merck "RotaTeq." RotaTeq rigakafi ne mai rai, na baka wanda ya ƙunshi nau'ikan rotavirus guda biyar da aka samar sake daidaitawa. Rotavirus Wani nau'in iyaye na reassortants an keɓe shi daga rundunonin mutane da na dabbobi. Wannan tsari ya ƙunshi ilimin ƙwayoyin cuta na gargajiya, kuma ba shi da alaƙa da fasahar da aka yi amfani da ita don gyara-mRNA rigakafin.
Dangane da maganganunsa da ke ƙasa, da yawa kamar yadda ya kasance tare da Dokta Peter Marks na FDA / CBER, ya bayyana cewa Dr. Offit ba shi da kwarewa tare da ko fahimtar ilimin kwayoyin halitta da kwayoyin halitta na zamani, kuma musamman tare da ko dai DNA ko mRNA transfection da in-vivo bayarwa - ta hanyar haɗin kai na cationic nanoparticles ko wata hanya kamar electroporation.
Ainihin, Dokta Offit tsohon masanin rigakafin rigakafi ne na makaranta, wanda a fili yake ba shi da horo ko gogewa a cikin ilimin halittar kwayoyin halitta na zamani, fasahar maganin kwayoyin halitta, ko rigakafin kwayoyin halitta. Wanda ke da ma'anar dagewar sa cewa waɗannan samfuran sun yi kama da tsofaffin alluran rigakafi na makaranta kamar samfurin sa na rayuwa. Abin baƙin ciki ga duka Dr. Offit da sauran mu duka, fasahar ta bambanta sosai, kuma tana da alaƙa da ilimin harhada magunguna fiye da tsohuwar ilimin rigakafi na makaranta.
Mai zuwa shine bayanin bayanin sharhin Dr. Offit dangane da Bayanin Dr. Joe Ladapo kamar yadda MedPage Today ta rubuta. Bari mu nutse don koyon abin da Dr. Offit yayi ko bai fahimta ba game da wannan takaddama.
Babban Likitan Likita na Florida Joseph Ladapo, MD, PhD, kwanan nan ya fitar da sanarwa cewa bai kamata a yi amfani da allurar rigakafin mRNA na Covid-19 ba. A cikin wannan hirar ta bidiyo, Paul Offit, MD, na Asibitin Yara na Philadelphia, ya tattauna maganar Ladapo da yadda ake yin alluran rigakafin.
Mai zuwa shine kwafin nasa tsokaci:
"A ranar 3 ga watan Janairun 2024, babban likitan fida na Florida, Dr. Joseph Ladapo, ya fitar da wata sanarwa. gargadi cewa likitoci da masu ba da lafiya a wannan jihar, Florida, kada su yi amfani da allurar mRNA. Dalili kuwa shi ne wai an gurbata su da gutsuttsuran DNARWM- sun gurɓata sosai, ba zato ba. An tabbatar da wannan gaskiyar ta dakunan gwaje-gwaje da yawa kuma FDA, Health Canada, da EMA sun tabbatar> wanda zai sa kansu cikin DNA na ɗan adam kuma zai iya haifar da ciwon daji kamar cutar sankarar bargo ko lymphoma ko cututtuka na autoimmune ko wasu matsaloli."
<RWM - An bayyana shi da kyau. Wannan ya faru ne daidai abin da jagorar ka'idoji na FDA da haƙƙin mallaka na Moderna suka yi gargaɗi game da gurɓacewar DNA na alluran rigakafi ko tushen tushen jiyya na DNA/gene.>
"Don haka ko hakan zai yiwu? Shin zai yiwu Dr. Ladapo ya yi daidai kuma saboda haka ya kamata mu guje wa alluran rigakafin da ke dauke da mRNA? Don fahimtar amsar wannan tambayar, kuna buƙatar fahimtar yadda ake yin allurar mRNA. Don haka, za mu fara a farkon.
Abin da kuke farawa da lokacin da kuke yin rigakafin mRNA shine ƙaramin madauwari plasmid na DNA, DNA mai madauri biyu, wanda aka saka kwayar halittar da ke lamba ga furotin na karu na SARS-CoV-2. Sai ku kara girman wannan plasmid a cikin kwayoyin cuta - kun yanke kwayoyin cutar, kun saki plasmid, sannan ku yanke wannan karamin DNA."
<RWM- Tsaya a nan. Wannan ba daidai ba ne. Ba za ku "yanke wannan ƙaramar DNA ba". Kuna tsarkake babban madauwari na plasmid DNA daga kwayar cutar lysate, wanda ke faruwa kuma ya haɗa da ɗan ƙaramin endotoxin. Tsarin tsarkakewa yana amfani da centrifugation. Nan take mun tabbatar da cewa Dr. Offit bai san me yake magana akai ba. Offit bai ɗauki ko ɗan ɗan lokaci ba don fahimtar tsarin masana'anta da aka yi amfani da shi a wannan yanayin.>
"Sa'an nan kuma ku yi amfani da enzyme, RNA polymerase, don canza wannan DNA zuwa RNA manzo."
<RWM: Bacteriophage T7 RNA polymerase, to be precise. As I originally pioneered in the takarda ta farko da ke nuna babban sikelin masana'anta, tsarkakewa, da kuma canjin lipid cationic na mRNA. Amma maimakon hada da tushen A, U, G, C kamar yadda na yi, kuna amfani da A, Pseudo-U da aka gyara, G, C.>
"Akwai matakan tsarkakewa iri-iri, akwai matakan tacewa, akwai jiyya tare da DNA ACE1, wanda shine enzyme wanda ke yanke DNA."
<RWM: Ba daidai ba kuma. Maganin yana tare da DNAse. Wataƙila kuskuren rubutu ne, wanda ya nuna cewa lokacin Ms. Hutto a matsayin “mai binciken benci” shima bai ƙunshi ilimin halitta ko ƙwarewar ƙwayoyin cuta ba.>
"To ko zai yiwu duk da tsarkakewa da tacewa an bar ku da ƴan guntuwar DNA? Ee, kai ne. Kuna da kusan biliyan ɗaya na gram, nanograms, na wannan rarrabuwar DNA."
<RWM: Wannan ba yuwuwa bane, gaskiya ne. Ƙarin hasken wuta. Ko inkari. Ko kuma kawai jahilci bayyananne. Wannan matakin babbar matsala ce a cikin aikin tsarkakewa, wanda shine dalilin da ya sa Moderna ya ba da takardar izini ta hanyarsu ta musamman na yin hakan. Wanda har yanzu bai yi aiki da kyau ba. Yawan ba shine batun nan ba. Batun shine ko akwai amintaccen madaidaicin gaɓoɓin gutsuwar DNA lokacin da aka ba da haɗin kai ta hanyar haɗin kai cationic lipid nanoplexes tare da gyara-mRNA. Idan haka ne, nuna mana bayanan da ke tabbatar da cewa wannan matakin zina ne mai aminci. Joe ya nemi FDA ta nuna waɗancan bayanan, kuma Daraktan FDA na CBER Peter Marks ya ba da amsa da ƙarya, ƙarya, hasken gas, da cikakkiyar gazawar bayyana irin waɗannan bayanan - waɗanda a fili babu su. Yayi kama da tsarin da Offit yayi amfani dashi anan. >
"Don haka DNA ɗin zai iya shafar DNA ɗin ku? Domin hakan ta faru, abubuwa uku za su faru, waɗanda galibi ba za su yiwu ba."
<RWM: Here is where this just interview veers into the childish and absurd. The process here is called DNA transfection. DNA transfection is a routine practice in virtually every molecular and cellular biology (and molecular virology) laboratory in the world. Ga takarda, wanda Offit yayi ikirarin ya saba da shi, wanda ke nuna cewa zaku iya samun DNA a cikin tsakiya na sel bayan mitotic - ergo ba rarrabawa - kuma zai yi mRNA da furotin. Kwayoyin tsoka. Ko da ba tare da cationic lipid nanoplexes ba. Tana da dubun dubatan littafai. An buga shi a cikin Kimiyya a cikin 1990. Ni ne marubuci na biyu. Na ji haushi. Shin da gaske Paul Offit wannan jahilci ne? Yana da wuya a yi tunanin cewa an amince da wannan mutumin don ba da shawarar FDA ko CDC akan waɗannan samfuran mod-mRNA.
"Na farko shi ne cewa DNA zai shiga cikin cytoplasm naka. Yanzu, cytoplasm din mu yana ƙin DNA na waje kuma yana da hanyoyi daban-daban, ciki har da hanyoyin rigakafi da enzymes, don lalata DNA na waje."
<RWM: This condescending explanation is partially true but substantially false. Transfected DNA gets into the nucleus of both mitotic and post-mitotic cells. Once again, every first-year graduate student working in cell and molecular biology or virology knows this.>
"Sa'an nan DNA, wanda ba zai taba tsira daga cytoplasm ba, dole ne ya ketare membrane na nukiliya zuwa cikin tsakiya, wanda zai buƙaci siginar samun damar nukiliya wanda waɗannan guntu na DNA ba su da."
<RWM: Yin wahala a faɗi menene ƙarya na niyya da abin da kawai jahilci ne mai zurfi. Matsalolin SV40 sun haɗa da siginar ganowa ta nukiliya (NLS), amma NLS ba lallai ba ne don canja wurin DNA. Duk dalibin da ya kammala karatun ilmin halitta na shekarar farko da kwayoyin halitta ya san wannan. DNA yana shiga tsakiya da kyau sosai. Musamman tare da electroporation. Amma wannan babban batu ne.>
"Ko da sun shiga cikin tsakiya, wanda ba za su iya ba, dole ne su shigar da kansu a cikin DNA ɗin ku, wanda ke nufin za su yanke DNA ɗin ku, wanda zai buƙaci enzymes kamar haɗin kai, wanda su ma ba su da shi."
"Don haka damar da DNA zata iya shafar DNA ɗinku ba komai bane."
<RWM: This is just pure propaganda. Contradicted by decades of FDA regulatory guidance, Moderna’s own patents, and what must be thousands of peer-reviewed publications concerning DNA delivery (transfection) into cells. I can only conclude that Offit is a shameless liar and propagandist. Just for kicks and giggles, I ran a PubMed search on the key word string “Plasmid DNA transfection”, which resulted in over 26,000 references. Duba da kanku ta hanyar danna mahadar da aka bayar.>
"Yana da ban sha'awa cewa a lokacin da kuka kawo ra'ayi na DNA na kasashen waje, mutane suna jin tsoro, dama? Domin DNA shine tsarin rayuwa, kuma ba ma so mu shafi tsarin rayuwarmu na rayuwa. Amma kuna fuskantar DNA na waje a kowane lokaci."
"Daya, kuna da tiriliyan na ƙwayoyin cuta da ke rayuwa a jikinku, wanda kuma DNA ɗin baƙon waje ne. Idan kuna tunanin kuna rayuwa a duniyar nan kuma kuna cin dabbobi ko tsire-tsire a wannan duniyar, kuna shigar da DNA na waje, wasu daga cikinsu suna shiga cikin ku - wanda aka tabbatar."
<RWM: Ba shi da mahimmanci. Sai dai cewa waɗannan ƙwayoyin cuta za su iya ɗaukar jerin juriya na Kanamycin da ke cikin guntun DNA na plasmid waɗanda ake allura..>
"Har ila yau, duk allurar rigakafin da aka yi a cikin sel, ko dai maganin kyanda, maganin mumps, rigakafin cutar kyanda na Jamus, rigakafin varicella, maganin rigakafi na rotavirus, rigakafin zazzabin rawaya - duk wani maganin kwayar cutar kwayar cutar da aka yi a cikin sel zai sami ragowar adadin DNA a cikin picogram (wanda shine trillion na gram) ba zai iya guje wa nau'in biliyan daya ba. haka.”
"Ina ganin ya kamata a tabbatar mana da cewa lokacin da kuka gutsuttsura wannan DNA kuma kuna da shi a cikin adadi masu yawa, da sanin abin da kuka sani game da rashin iyawar waɗannan ɓangarorin DNA ɗin don samun damar shiga cikin tsakiyar ku kuma su cutar da ku, yana da wuya a yarda cewa Dr. Ladapo ya fitar da wannan sanarwa."
"Abin ban mamaki, ya ce ya kamata ku yi amfani da wasu alluran rigakafin Covid. Sauran rigakafin Covid da aka ba da lasisi ga mutane sama da 12 a cikin wannan ƙasar ita ce rigakafin Novavax. Ana kuma yin allurar Novavax a cikin sel. Abin da ake kira baculovirus expression vector."
RWM: A'a, Paul, ba maganin baculovirus ba ne. Har yanzu, Dr. Offit ya bayyana jahilcinsa na asali. Tsaftataccen maganin rigakafin furotin ne, wanda aka tsara shi da wani sabon abu adjuvant. Ana samar da bangaren furotin a cikin ƙwayoyin kwari bayan kamuwa da cuta tare da kwayar cutar recombinant kwaro (caterpillar). Wani tsarin da nake da zurfin ilimi da fahimta.
"Baculovirus ta shigar da kwayar halittar kwayar halittar da ke dauke da sunadarin furotin na SARS-CoV-2. Daga nan sai ta shiga cikin sel, ana kiranta kwayoyin. Spodoptera frugiperda Kwayoyin ko Sf9, don haka za ku sami ragowar DNA a can kuma. Babu dai gujewa hakan.”
<RWM: Ee, akwai DNA tantanin kwarin da suka rage. Amma ba a nannade shi da kai-hada cationic lipid bayarwa nanoparticle. Bulus bai fahimci batun Joe ba, duk da cewa Dr. Ladapo ya fayyace hakan a fili a cikin bayaninsa.>
"Ma'anar ita ce a sami shi a cikin ƙananan matakan da ba zai iya cutar da shi ba. Don haka tsoratar da mutane ba tare da la'akari da haka ba yana da wuya a kalla. Da fatan, wannan ya kasance mai kwantar da hankali."
Ta hanyar shawarwari masu taimako, Dr. Offit ya kamata ya ɗauki ɗan lokaci don karanta waɗannan abubuwa kafin ya kunyata kansa (kuma ya yaudari jama'a) ya ci gaba:
Jagora ga Masana'antu Abubuwan da ake la'akari don Nazarin Ci gaba na Guba don Rigakafin Rigakafi da Magunguna don Alamun Cutar Cutar
Redbook 2000: IV.B.1. Gabaɗaya Jagora don Tsara da Gudanar da Nazarin Guba
Ƙaddamarwa da fassarar ma'anar warkewa a cikin ci gaban ƙwayoyi
Wato kawai tabo ne.
Kuma yayin da nake kan haka, ga wata magana wacce ta fi dacewa da halin da ake ciki a masana'antar rigakafin Dr. Offit:
Kesselheim, AS Ba da izinin ƙarar abin alhaki na samfur don magungunan da aka amince da FDA da na'urori suna haɓaka amincin haƙuri. Clin. Pharmacol. Ther. 87, 645-647 (2010).
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