Biliyoyin daloli ana kashewa kowace shekara
Neman maganin ciwon daji
Me zai hana a kashe wannan kuɗin maimakon
Don kawar da gurbatar yanayi da ke haifar da ciwon daji
Ta hanyar nazarin DNA
Wata rana za mu iya cin nasara akan cuta
Baby "cikakken" kowane lokaci
Ta hanyar taswira da sarrafa kwayoyin halittar mutane
Inshorar rayuwa? Ku kasance da gaske!
Dole ne a fara tantance kwayoyin halittar ku
Magunguna masu guba? Fus a wurin aiki?
Babu gumi! Samun dashen kwayoyin halitta
In ba haka ba za ku rasa aikinku
Kuna so ku tashi a cikin tituna?
Kuma ku rena yaranku a sansani da matsuguni?
Kuma bara a ci abinci
Yaƙin ƙwayar cuta, ƙarin bama-bamai
Yaƙin ƙwayar cuta, ƙarin bama-bamai
Dukan tattalin arzikinmu ya dogara ne akan tsoro da mutuwa
Har yaushe za mu rabu da wannan?
Mutane ba daidai ba, daidai wurin
Ajin mulki yana samun fasinja kawai
Don shiga cikin jirgin don sararin samaniya
A 2030, wannan wurin fa?
Jello Biafra da NOMEANSNO lyrics. Sama Ya Fado Ina Son Mamana. 1991
An yi nufin in yi magana na kusan mintuna 15 a wani koma baya na Brownstone na kwanan nan kuma na sami kaina ina yin shawagi na linzamin kwamfuta akan batun maganin cutar kansa na kusan mintuna 5 maimakon. Ina tsammanin yana da mahimmanci. A cikin Janairu 2024, da Lancet ya rubuta wani bincike mai suna "MRNA-4157 (V940) da pembrolizumab tare da pembrolizumab monotherapy a cikin melanoma mai lalacewa (KEYNOTE-942): bazuwar, Phase 2b binciken"wanda shine taƙaitaccen bayanan gwaji na lokaci 2 na wannan 'sabon' samfurin. Kuna iya karantawa game da hakan nan, kuma ga bayanin binciken gwaji na asibiti a gwaji na asibiti dot gov NCT03897881.
A halin yanzu, muna tafiya zuwa mataki na 3, kuma kafin ku san shi, kowa zai yi allurar mRNA da aka gyara don 'warkar da kansa.' Yanzu kar a gane ni ba daidai ba, ciwon daji yana da wayo kuma yana buƙatar magance shi, amma kamar yadda na bayyana a cikin gajeriyar mintina 5, ciwon daji kusan kusan ana iya yin rigakafinsa (a cikin yanayin yawancin cututtukan daji) don haka, yakamata a kashe albarkatun don rigakafin, ba mataki na 4 'maganin' ya dogara da sabbin magunguna na tushen tushen kwayoyin halitta waɗanda ke da ingantaccen bayanin martabar aminci kamar yadda aka yi gwajin samfurin Covid-19.
A ranar 26 ga Afrilu 2024, Sky News ta rubuta labarin da ke taƙaita 'labarai masu kyau' game da wannan sabon 'maganin'. Sun ba shi taken: "Jab na farko a duniya don dakatar da gwajin cutar kansar fata a cikin marasa lafiya na Burtaniya." Yana da ban sha'awa a gare ni cewa ba a ambaci mRNA da aka gyara ba, kuma yana ba ni haushi cewa suna kiran mutane a matsayin marasa lafiya. Na ƙi hakan. Mu ba marasa lafiya ba ne har sai mun kasance a hannun likita / wurin likita. Yana kusan kamar suna priming mu don rayuwa a cikin ‘sabuwar duniya’ inda za a haife mu duka kamar marasa lafiya.
Wannan 'maganin' ko jiyya, idan kuna so, ya dogara ne akan ra'ayi mai suna Individualized Neoantigen Therapy (INT), wanda a cikin kanta, ra'ayi ne mai hazaka, duk da haka ba dole ba. Tunda wannan maganin ya dogara ne akan dandamalin 'gargajiya' Covid-19 samfurin lipid nanoparticle (LNP), yana da haɗari a zahiri, a ganina.
Antigen kwayoyin halitta ne wanda ke da ikon samun antibody da aka haifar dashi. Neoantigens suna da takamaiman ƙari kuma ƙwayoyin cutar kansa ke samarwa. Kwayoyin ciwon daji suna da tushensu a cikin takamaiman maye gurbi na DNA wanda ke haifar da samar da neoantigens. Neo ya zo daga Girkanci neos ma'anar 'sabo', don haka waɗannan neoantigens sababbin antigens ne (ƙayyadaddun ƙwayar cuta) wanda tsarin rigakafi ba a gani ba tukuna.
Tunanin da ke cikin gwaji na asibiti na lokaci na 2 ya zuwa yanzu, shi ne cewa cutar kansar melanoma za a iya biopsied, DNA ɗin da ke cikinta mai zurfi, da DNA na keɓaɓɓen neoantigens masu alaƙa da ƙari da aka gano. Tare da waɗannan a hannu, ana iya yin laifin da aka yi niyya akan takamaiman ƙwayoyin cutar kansa.
Anyi amfani dashi tare pembrolizumab, sun yi iƙirarin cewa an rage sake dawowar ciwon daji idan aka kwatanta da amfani da pembrolizumab kawai. Wannan gwaji na asibiti ya fara ne a watan Yuli 2019 kuma an gabatar da ƙaddamar da farko a cikin Maris 2019. Abin ban dariya.
Abubuwan mRNA da aka yi amfani da su azaman abin biya har ma suna da shafin Wikipedia. Nemo mRNA-4157/V940. Kamar yadda aka ambata, motar isarwa ita ce LNPs waɗanda kamar yadda muka sani a yanzu, ana yin su tare da manyan lipids cationic masu caji - iri ɗaya waɗanda aka san suna da manyan bayanan guba a cikin ɗan adam. Haka waɗanda aka yi amfani da su don isar da ingantaccen mRNA da aka yi amfani da su a cikin hotunan Covid.
Waɗannan LNPs har yanzu ba su da wani binciken da ke da alaƙa da amfani da su a cikin rashin kayan aiki, kamar yadda na sani. Na yi imani cewa fiye da guba na cationic lipids, waɗannan LNPs suna da haɗari sosai dangane da yuwuwar su na tarwatsewa. zeta yuwuwar ƙwayoyin jajayen jini. Mu kawai mun san abin da yuwuwar zeta ke cikin mahallin samfuran Covid - ana nufin ya zama 3.13 mV - amma shin? Shin suna da ma da tsaka-tsakin yuwuwar zeta?
Ina son wannan labarin Sarah Whelan ta rubuta don Cibiyar Sadarwar Fasaha ta bayyana abin da neoantigens suke, yadda suke tasowa, da kuma yadda 'maganin ciwon daji' na iya aiki a cikin mahallin su. Ta shiga cikin bambance-bambance tsakanin keɓaɓɓun neoantigens da aka raba a cikin mahallin antigens na kansa.
Hoto na 1: Ciro daga labarin Hanyoyin Sadarwar Fasaha ta Sarah Whelan: Menene Neoantigens? Source: https://www.technologynetworks.com/cancer-research/articles/what-are-neoantigens-372277.
Maganin tushen kwayoyin halitta yana kaiwa waɗannan takamaiman antigens ta hanya mai zuwa.
Matsalolin mRNA da aka gyara a cikin LNPs - mRNA-4157 - jerin nucleotides ne, kamar na furotin mai karu, wanda ke ɓoye 34 da aka gano neoantigens kuma akan canzawa ta amfani da LNPs azaman dawakai na trojan, injin na'ura mai watsa shiri yana fassara mRNA na roba zuwa sunadarai masu zuwa. Wadannan sunadaran suna sarewa da zarar an samar da su ta hanyar enzymes cell cell na asali, kuma suna hawa akan kwayoyin MHC a matsayin peptides na antigenic a wajen tantanin halitta. Wannan wani bangare ne na sarrafa antigen na ciki na al'ada kuma a zahiri, tsarin aikin da aka tsara don wannan 'farkon'. Kwayoyin T da za su iya gane peptides da aka gabatar a kan kwayoyin MHC zasu amsa ta hanyar kashe tantanin halitta, idan sun kasance CTLs, alal misali. Don haka mabuɗin a nan, a ra'ayi na, shine a yi niyya - daidai - ƙwayoyin cutar kansa tare da LNPs.
Game da mRNA-4157 (V940)
mRNA-4157 (V940) sabon labari ne na manzo bincike RNA (mRNA) - tushen jiyya na neoantigen (INT) wanda ya ƙunshi coding mRNA na roba don har zuwa 34 neoantigens waɗanda aka ƙirƙira kuma aka samar bisa keɓaɓɓen sa hannu na mutational na jerin DNA na ciwon mara lafiya. Bayan gudanarwa cikin jiki, abubuwan da aka samu ta algorithm da RNA-encoded neoantigen ana fassara su gabaɗaya kuma ana gudanar da aikin sarrafa antigen na salula na halitta da gabatarwa, babban mataki na rigakafin daidaitawa. An tsara magungunan neoantigen daban-daban don horarwa da kunna martanin rigakafin rigakafi ta hanyar samar da takamaiman martanin T-cell dangane da sa hannu na musamman na majiyyaci. tumo.
Don haka abin da zai yi mini aiki, ba zai yi muku aiki ba. Yana da kyau, amma ba zan taɓa cin abinci ba. Ina buƙatar ƙarin sani game da tsarin niyya game da ƙwayar cutar kanta, kuma ba shakka, wasu nazarce-nazarce kan LNPs mara kyau, don Allah.
The NCT03897881 Bayanin gwaji na asibiti na kashi 2 (ranar farawa: 2019-07-18; ƙarshen kwanan wata: 2029-09-09) ya bayyana cewa mahalarta gwajin sun sami har zuwa allurai 9 na samfurin mRNA-4157 kowane kwanaki 21 (ƙarashin kashi) amma ba a bayyana ba. yaya ana gudanar da su. Shin suna gida ne zuwa wurin melanoma? Shin suna cikin tsoka kamar harbin Civud? Suna kawai rubuta "Individualized Neoantigen Therapy". Su do gaya mana cewa pembrolizumab jiko ne na jijiya.
Hoto na 2: An Ciro daga Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun NCT03897881 nazarin binciken. Source: https://clinicaltrials.gov/study/NCT03897881.
The NCT03313778 Bayanin gwaji na asibiti lokaci na 1 (ranar farawa: 2017-08-14; ƙarshen kwanan wata: 2029-09-09) yana bayyana dabarun allura na ciki. Wannan abin damuwa ne. Mai matukar damuwa. Zan yi daidai in zaci cewa "Cibiyar Neoantigen Farko" ta atomatik yana nufin allurar cikin tsoka. Zan yi daidai in ɗauka cewa za a gudanar da wannan a hannu, kamar yadda aka yi harbin Covid.
Daga nan zan zama daidai in ɗauka cewa LNPs, sai dai idan an tsara su don gudanar da niyya, za su je ko'ina, kamar yadda suka yi da COVID LNPs. Shin wannan ba lallai ba ne yana nufin cewa kwayoyin halitta bazuwar za su kamu da cutar kuma ta haka ne su samar da neoantigens na kansa kuma su dora su a saman su don takamaiman kisa?
Hoto 3: An Ciro daga Ƙwararren Ƙwararrun Ƙwararrun Ƙwararrun NCT03313778 nazarin binciken. Source: https://www.clinicaltrials.gov/study/NCT03313778
A kan batun takamaiman LNPs, a cikin labarin daya da na karanta a cikin tafiya ta bincike akwai ambatonsa Onpattro, kuma idan kun saba da zamani labaran nawa, kun san cewa wannan magani ne na tushen LNP wanda ke amfani da takamaiman LNPs waɗanda ke kaiwa hanta ta amfani da su APOE sunadaran a saman LNPs. Tambayata a yanzu ita ce, ana amfani da LNPs don isar da mRNA-4157 takamaiman, kuma idan haka ne, ta yaya ake niyya kuma a ina aka keɓance su? Shin an haɗa su da neoantigens kuma idan haka ne, ta yaya hakan zai yi aiki? Ina tsammanin babu masu karɓa na cognate don neoantigens.
Don samun LNPs zuwa sel mai yiwuwa su sami takamaiman maye gurbi na DNA da ke da alaƙa da melanoma, zan yi tunanin zai fi kyau a yi allurar LNPs a wurin da aka cire (cire) melanoma ta amfani da allurar subcutaneous. Amma me na sani?
Shi ke nan a yanzu. Shirya don amfanin gama gari na kalmomin "maganin ciwon daji", "maganin keɓaɓɓen magani", da "maganin halitta" a matsayin wani ɓangare na sabon ƙamus na duniya. Hakanan za su daidaita tsarin CRISPR/Cas-9 kuma maimakon ɗaure maza kamar. Shi Jiankui, za su ba su kyautar Nobel nan ba da jimawa ba. Kalla kawai.
Karanta kowace kalma na waɗannan waƙoƙin da aka rubuta shekarun da suka gabata…
Na farko gwajin fitsari - yanzu wannan!
Na farko gwajin fitsari - yanzu wannan!
Me yasa duk mafi kyawun ci gaban fasaha
Koyaushe tashi cikin mafi munin hannaye
Ta hanyar nazarin DNA
Wata rana za mu iya cin nasara akan cuta
Baby "cikakken" kowane lokaci
Ta hanyar taswira da sarrafa kwayoyin halittar mutane
Yin tiyatar kwaskwarima kafin a haife ku
Ku sani a gaba abin da za ku mutu da shi
Kowa yana da amfani kuma iri ɗaya ne
Masu ninkaya suna yin kiwo kamar dawakai don ƙungiyoyin Olympics
Inshorar rayuwa? Ku kasance da gaske!
Dole ne a fara tantance kwayoyin halittar ku
Magunguna masu guba? Fus a wurin aiki?
Babu gumi! Samun dashen kwayoyin halitta
In ba haka ba za ku rasa aikinku
Kuna so ku tashi a cikin tituna?
Kuma ku rena yaranku a sansani da matsuguni?
Kuma bara a ci abinci
Akwai kifin sharks da yawa a cikin tafkin
Da yawa sun tauna gawa a bakin tekun
Sharks da yawa a cikin tafkin gene
Rago da yawa suna ruɓe a kusa da mu
Na farko gwajin fitsari - yanzu wannan!
Me yasa mafi kyawun ci gaban fasaha
Ci gaba da tashi kamar yadda…
Uniform nau'in nau'in nau'in nau'in nau'i
Don abinci mai hana kwari masu kama da sabo
Apple zai iya zama a kan shiryayye na shekaru
Lokacin da muka haskaka kwayoyin halitta
Amma ina abinci ya tafi?
Kuma me aka ɗauke shi?
Slipshod yana lalata da kimiyya
Ma'aikata na gona eugenics ba su da iko
Makarantun yanka a lowwa
Cike da shanu masu ciwon kumburi
Gwaje-gwajen da ba a yi nasara ba sun ɓoye 'har sai an sayar
Zuwa shirin abincin rana na makarantar ku
Grade D, amma edible
Abincinmu, rayuwarmu, halinmu
Shaƙewa cikin abin da muka ƙi sake yin fa'ida
Bama-bamai na lokaci suna tashe a kowane gari
Biliyoyin daloli ana kashewa kowace shekara
Neman maganin ciwon daji
Me zai hana a kashe wannan kuɗin maimakon
Don kawar da gurbatar yanayi da ke haifar da ciwon daji
Akwai kifin sharks da yawa a cikin tafkin
Yawan dunƙule-ƙulle-ƙulle yana wanke bakin ruwa
Sharks da yawa a cikin tafkin gene
Hatsarori da yawa da za a iya rigakafin su a tsakaninmu
Meryl Streep… ina kuke?
A ina Amurka ta san yadda za a
Me yasa Jafananci ke gina sitiriyo mafi kyau
Shin 'kos mafi kyawun tunaninmu ba zai iya samun aiki ba?
Sai dai lokacin da suke taimakawa yin kayan wasan yara don Pentagon
Yaƙin ƙwayar cuta, ƙarin bama-bamai
Yaƙin ƙwayar cuta, ƙarin bama-bamai
Dukan tattalin arzikinmu ya dogara ne akan tsoro da mutuwa
Har yaushe za mu rabu da wannan?
Kuma muna zaune a nan
Maimakon ingantacciyar lafiya muna samun AIDS
Maimakon abinci mai gina jiki muna samun steroids
Mafi shaharar zaɓe a bankunan maniyyi masu shahara
Jaruman wasanni ne
Rata ta fadada tsakanin masu hannu da shuni
Mawadaci da iko iri ne kawai tare da kansu
Dukanmu mun san abin da ke faruwa idan yawancin wannan ya faru
Zuriyar ba ta da haske kawai
Ta yaya kuma za ku iya bayyanawa
Rushewar basira da abin hangen nesa
Har zuwa inda mafi kyawun abin da za su iya fitowa da shi
Domin abin koyi da jagororinmu na gaba
Mugayen injunan makafi ne
Kamar Albert Gore da Dan Quayle
Me yasa mafi kyawun mafita da ci gaba
Jefa a cikin mafi munin hannaye
Akwai kifin sharks da yawa a cikin tafkin
Gawawwaki da yawa suna wankewa a bakin teku
Sharks da yawa a cikin tafkin gene
Guguwar gutsi mai guba a kewaye da mu
Ba mu da kwarewa a matsayin mutane
Ko mafi muni a wasa da Allah
Mutane ba daidai ba, daidai wurin
Ajin mulki yana samun fasinja kawai
Don shiga cikin jirgin don sararin samaniya
A 2001, wannan wurin fa?
An sake bugawa daga marubucin Mayarwa
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Dokta Jessica Rose ma'aikaciyar Cibiyar Brownstone ce kuma tana da BSc. a cikin Ƙwararren Lissafi, MSc. a cikin Immunology, PhD a cikin Biology na Kwamfuta da alƙawura biyu na digiri na biyu a cikin Kwayoyin Halitta da Biochemistry. Jessica tana aiki don wayar da kan jama'a game da bayanan VAERS.
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