Moderna Spikevax-FDA Postmortem

Alamar fakitin da ta ƙare don samfurin Moderna Spikevax 24-25 da aka sabunta. Sabbin FDA-an yarda Alamar alama za ta nuna "tsawon watanni 6 zuwa shekaru 11 waɗanda ke cikin haɗarin kamuwa da cutar COVID-19 mai tsanani."

Me ya faru a ranar 10 ga Yuli?

Na sami buƙatu da yawa don fayyace abin da ya faru tare da kwanan nan Yuli 10, 2025, FDA general (ba EUA) izinin tallan na Moderna's SpikeVax ga yara. Gaskiyar lamarin ita ce, ban san ainihin abin da ya faru a FDA ba don haifar da wannan sakamako. Kamar mutane da yawa, na yi mamaki da takaici. Moderna ta yi murna. Ƙimar hannayen jari da ƙimar kasuwancinsu ya ƙaru, tare da hawan hawan kwanaki huɗu kafin sanarwar, wanda ke nuna cewa wani yana da masaniya. Idan gaskiya ne, hakan zai iya zama ciniki na ciki. Wannan zai zama daidai nau'in karya doka da mutane da yawa suka yi tsammani daga wannan kamfani da sashin. Kuna iya ɗaukar wannan hasashe, don dalilan wannan tattaunawa.

Moderna's Spikevax Covid-19 rigakafin sun sami cikakkiyar amincewar FDA ga yara masu shekaru 6 zuwa shekaru 11 waɗanda ke cikin haɗarin haɗarin cutar Covid-19 mai tsanani., kamar yadda aka sanar a ranar 10 ga Yuli, 2025. Wannan amincewar ta canza maganin daga samuwarta ta farko a ƙarƙashin Izinin Amfani da Gaggawa (EUA) na wannan rukunin shekaru. An amince da Spikevax a baya ga manya masu shekaru 65 da haihuwa, da kuma mutanen da ke da shekaru 6 zuwa watanni 64 a cikin haɗarin kamuwa da cuta mai tsanani.

Moderna's Spikevax ya kasance da farko an ba da izinin FDA a cikin Janairu 2022 don amfanin manya. Tun daga lokacin da aka sami sabuntawar rigakafin, gami da yin niyya ga bambance-bambancen KP.2 na SARS-CoV-2, kuma an faɗaɗa shi don rufe manyan ƙungiyoyin shekaru. Moderna yana shirin samar da sabbin rigakafin Spikevax don samar da yawan jama'a a cikin Amurka gabanin lokacin cutar numfashi na 2025-2026.

Amincewar ta dogara ne akan nazarin kimiyya na FDA, tare da Shugaba na Moderna, Stéphane Bancel, yana mai da hankali kan ci gaba da barazanar Covid-19 ga yara, musamman waɗanda ke da yanayin rashin lafiya. Duk da amincewar, masu sukar sun tayar da damuwa game da rashin bayanan lafiyar yara da kuma yuwuwar haifar da mummunar mummunan al'amura, ciki har da myocarditis da pericarditis. Fakitin Spikevax ya lissafa abubuwan da ba su da kyau, kamar matsalar numfashi, kumburin fuska da makogwaro, saurin bugun zuciya, dizziness, da rauni.

FDA da Moderna sun yarda da waɗannan haɗarin, kuma abubuwan da aka sabunta a cikin kunshin yanzu sun haɗa da faɗakarwa masu ƙarfi game da myocarditis da pericarditis. An yi nufin maganin alurar rigakafin ga mutanen da ke cikin haɗarin kamuwa da cuta mai tsanani, kuma rigakafin ba zai iya kare duk mutanen da suka karɓi maganin ba.

Moderna kuma yana da wasu alluran rigakafi a cikin fayil ɗin sa, gami da mNEXSPIKE (mRNA-1283), wanda aka amince da shi a watan Yuni 2025 ga manya masu shekaru 65 da haihuwa da kuma mutane masu shekaru 12 zuwa 64 da aƙalla haɗarin haɗari na cuta mai tsanani. Wannan amincewa ya dogara ne akan bayanai daga gwaji na Mataki na III na NextCOVE, wanda ya nuna cewa mNEXSPIKE ba shi da ƙasa da Spikevax.

Akwai Tambayoyi da yawa da ba a warware su ba dangane da wannan aikin. 

1. Me yasa aka amince da Moderna's Spikevax don wannan nuni kuma baya samar da irin wannan amincewa ga samfurin Pfizer? 
2. Shin Kwamishinan FDA Dr. Marty Makary ya san kuma ya amince da wannan shawarar, ko kuma an yanke shawara kuma an yi aiki da shi a matakin Cibiyar Nazarin Halittar Halitta ta FDA (CBER) Vinay Prasad?
3. Shin lokacin wannan shawarar ya faru ne yayin da duka Sakatare Kennedy da mataimakinsa Stephanie Spear suka tafi hutu kwatsam?
4. Shin an yanke wannan shawarar ne a cikin mahallin babban tsari a cikin HHS?
5. Menene sharuɗɗan da suka gabata waɗanda FDA ta ɗauka azaman sanyawa "Yara masu shekaru 6 zuwa shekaru 11 a cikin haɗarin haɗari mai tsanani na COVID-19. A wasu kalmomi, ta yin amfani da yare bayyananne, mene ne takamaiman cututtukan ƙuruciya da ɗanku zai iya samu wanda zai sa su cancanci wannan samfur mai lasisin FDA?
6. Menene kuma a ina ne bayanan da ke nuna cewa fa'idodin karɓar wannan samfurin ya fi haɗari ga yara masu waɗannan takamaiman cututtuka? Shin za a ba wa likitocin likita da iyaye damar ganin bayanan bincike na haɗari / fa'ida, wanda (mai yiwuwa) FDA ta yi amfani da ita don tabbatar da wannan shawarar? 
7. Menene adadin"Yara masu shekaru 6 zuwa shekaru 11 suna fuskantar haɗarin kamuwa da cutar COVID-19 mai tsanani" waɗanda ke buƙatar kulawa da wannan samfur don hana mutuwa ɗaya ko kuma asibiti guda ɗaya da za a iya gujewa ba tare da shakka ba saboda mummunar cutar Covid-19? Za a ba mu damar ganin wannan lissafin don kowane yanayin da FDA ta rigaya ta ƙayyade kamar yadda ke da alaƙa da "Haɗarin haɗari ga mummunan cutar COVID-19? ” Waɗannan su ne bayanan da likitocin yara da iyaye ke buƙatar yin zaɓin da suka dace game da karɓar wannan samfurin ga yaransu.

Kwanaki na juriyar jama'a na halayen FDA na uba na "Mu ne ƙwararru kuma mun fi sani, don haka ba kwa buƙatar ganin bayanan da nazarin mu" sun ƙare. 

Nuna mana bayanan. A bayyane kuma mai sauƙi.

Amma wa zai yi magana ga wadanda suka jikkata? Wa zai kare iyaye da ’ya’yansu? Don a fayyace, FDA/CBER sun ba da izinin tallan tallace-tallace gabaɗaya don wannan samfurin, amma wa zai yanke shawarar yadda ya kamata a yi amfani da shi? Tabbas, a cikin duniyar hankali, ɗaiɗaikun likitocin yara, manyan likitocin, da iyayen da ke ba da izini na gaba suna kan gaba don wannan shawarar. 

Amma gaskiyar ita ce, aikin likitanci a Amurka an ƙaddara shi ta hanyar alhaki na doka. Abubuwan alhaki na shari'a suna fitar da komai, daga ofishin likita har ta hanyar asibitoci da tsarin "kiwon lafiya", har zuwa kamfanonin inshora. Kuma abin alhaki na shari'a ya ta'allaka ne kan ko an cika "ma'aunin kulawa" ko a'a a cikin shari'ar mutum ɗaya. Dangane da masu kera alluran, sun yi nasarar jan kunnen gwamnati game da cikakken garkuwar abin alhaki, don haka a ma’ana, ba su da kare a cikin wannan fadan, sai dai tsarin kulawa ya kayyade yawan adadin kayayyakin da za su iya siyar. 

Wanene zai kafa ma'aunin kulawa kamar yadda ya shafi wannan samfurin?

A tarihi, amsar ita ce Kwamitin Ba da Shawarwari na CDC akan Ayyukan rigakafi (ACIP). Wannan hujja mai sauƙi ta haskaka dalilin da ya sa kamfanonin watsa labaru na Pharma duk sun kasance suna tafiya a wata a kan shawarar da Sakatare Kennedy ya yanke na janye tsohuwar ACIP da ta zama tambarin roba don FDA da Pharma, da kuma maye gurbin shi tare da mambobin da za su dage kan tantance ainihin bayanan da ke tallafawa (ko a'a) yin amfani da lasisin kamuwa da cutar (kayayyakin rigakafin cutar ko abubuwan da ke da alaƙa). 

Can za ka kara wancan? Dangane da amfani da kalmar kamar yadda Robert Heinlein ya tsara a cikin rashin mutuwa.Baƙo a Ƙasar Baƙi,” ma’ana zurfafa fahimtar wani abu a matakan tunani, hankali, da zamantakewa.

A fasaha, bisa tsarin mulki, FDA/CBER yana ba da izini don jigilar jihohi da tallan samfuran likita da na'urori. CDC/ACIP tana ba da shawarwari ga Daraktan CDC (da Sakatare na HHS) akan ma'auni na kula da rigakafin cututtuka da samfuran da ke da alaƙa. Shawarwari na ACIP sun zama shawarwarin manufofin CDC na hukuma ne kawai bayan Daraktan CDC ya yarda da su. Daraktan CDC na iya kuma ya ƙetare shawarwarin shawarwarin ACIP a lokuta da ba kasafai ba.

Ta hanyar shata, ana buƙatar ACIP don ɗaukar batun wace shawara don samar da Daraktan CDC a taron ACIP na gaba, bayan izinin FDA na sabon samfurin rigakafin. ACIP ta gaza cika wannan buƙatu a cikin yanayin samfurin Moderna na FDA kwanan nan mNEXSPIKE. Ban sani ba ko ko lokacin da ACIP na iya magance wannan aikin na FDA.

Game da izinin sayar da FDA na kwanan nan don Spikevax, menene ACIP zai yi yanzu? Abin takaici, a matsayin memba na ACIP (dukkanmu "masu aikin sa kai ne," ta hanya), an hana ni yin sharhi game da tsare-tsaren ACIP na gaba fiye da abin da ke cikin bayanan jama'a, wanda yake kamar yadda ya kamata. Ba, kuma ba zan iya ba, magana ga ko dai ACIP, CDC, ko Gwamnatin Amurka, kuma shawarwarin ACIP da tsare-tsare na cikin gida ana ɗaukar bayanan sirri. 

Duk wannan shine a ce darektan FDA/CBER Vinay Prasad ya jefa dankalin turawa mai zafi daidai a cinyar ACIP, wanda yanzu ya tsaya tsakanin wannan shawarar FDA da miliyoyin iyayen Amurka da 'ya'yansu. To, a zahiri, duk abin da ACIP ke yi shi ne nasiha ga Daraktan CDC, wanda a halin yanzu yana jiran amincewar Majalisar Dattawa. Kuma kun san abin da hakan ke nufi. Dr. Prasad ya kuma jefa wannan dankalin turawa mai zafi a cikin kayan aikin tabbatar da Majalisar Dattawa. 

Kawai don bayani da mahallin, Moderna yana ba da hujjar gabatarwa da tallata samfurin mNEXSPIKE a layi daya da samfurin Spikevax kamar yadda yake ba da fa'idodin ƙira wanda zai ba da kariya a kashi ɗaya cikin biyar na adadin Spikevax kuma yana ba da damar ajiya tsakanin 2 ° C da 8 ° C har zuwa kwanaki 90. Spikevax zai iya zama adana a waɗannan yanayin zafi har zuwa kwanaki 60. 

Za a iya ajiye sabon maganin a zazzabi na 8°C zuwa 25°C har sau biyu idan dai Spikevax. Abubuwan haɓakawa sun samo asali ne daga bambance-bambance a cikin ƙirar rigakafin. Spikevax encodes wani gyare-gyaren sigar cikakken furotin karu na ƙwayar cuta, wanda aka nuna yana da alaƙa da nau'in guba mai yawa. Sabuwar alurar riga kafi ta ƙunshi haɗin mai karɓa da wuraren N-terminal na ƙwayar cuta. Gajeren tsayin mRNA is hade tare da ƙara kwanciyar hankali. Mai yiwuwa, wannan sigar sake fasalin furotin mai tsayi mai tsayi shima ba zai rasa sanannun abubuwan da ke da alaƙa da nau'ikan furotin na Spike da aka canza ba da kuma gyare-gyaren sunadaran Spike da aka yi amfani da su a kusan duk sauran samfuran Covid-19 da aka ba da izinin FDA.

Wanene Ya Sani, Me, Da Yaushe, Kuma Shin Akwai Manyan Dabaru da La'akari da Dabaru?

Ina da iyakataccen gani cikin waɗannan tambayoyin. Gaskiyar rashin tausayi shine wannan shawarar game da izinin FDA/CBER Spikevax "ga yara masu shekaru 6 zuwa shekaru 11 waɗanda ke cikin haɗarin kamuwa da cutar COVID-19 mai tsanani" Moderna ya bayyana a bainar jama'a lokacin da duka Sakataren HHS (JFK, Jr.) da amintaccen mataimakin shugaban ma'aikata, Stefanie Spears, ke hutu. 

Babu Sec HHS ko mataimakinsa Shugaban Ma'aikatan (dCOS) da aka yi bayani ko karantawa game da wannan shawarar. Shin Kwamishinan FDA ya sani? Shin (misali) Shugaban Ma'aikatan HHS Heather Flick ya sani? Shin POTUS ko COS ya sani? Ban san amsoshin waɗannan tambayoyin ba. Abin da na sani shi ne, jim kaɗan bayan Sakataren HHS da dCOS sun dawo daga hutu, an sami babban sake fasalin shugabancin HHS. Kuma an yi wa POTUS da COS bayanin wannan shawarar. Yanzu akwai sabon shugaban ma'aikatan HHS. DCOS for Policy An fita daga cikin harabar kuma ta baci sosai har ta yi karo da motarta cikin motar da Sakatariyar ta samar. Kuma ina jin bugun ganga a nesa yana nuna cewa ƴan ƙasar sun yi imanin ƙarin canje-canjen ƙungiyar za su zo.

Ga waɗancan, gami da ni kaina, waɗanda suka nace cewa akwai sakamako na rashin taƙaita jerin umarni game da wannan yanke shawara mai ban takaici na darektan FDA/CBER, akwai kwanciyar hankali a cikin sanin cewa akwai sakamako mai sauri. Ko kun yarda ko ba ku yarda da shawarar ba, ina fatan kowa zai iya fahimtar cewa dole ne hukumomin tarayya su gane cewa za a sami sakamako na gazawar taƙaita jerin umarninsu game da yanke shawara na siyasa. Wani ɗan gajeren firgita mai kaifi shine daidai abin da likita ya ba da shawarar.

Game da Dabaru da Dabaru

Labarin akan MAHA Twitter bayan FDA ta amince da rigakafin SPIKEVAX na Moderna ga yara masu haɗari shine cewa wannan cin amana ce ta Sakatare Kennedy. Amma wannan shine kishiyar abin da ya faru. Sakataren ya tafi hutu kuma ba a yi masa bayanin shawarar ba. Hutu ce ta aiki, kuma ina da tabbaci na sirri cewa ya ɗauki kira da yawa, taƙaitaccen bayani, kuma koyaushe yana sarrafa dabaru da shawarwari a lokacin hutun da ake buƙata da kuma samun riba sosai. Shi (da matarsa da yake ƙauna) ba su samu hutu ba tun da ya ƙaddamar da yakin neman zabensa na Shugaban Ƙasa.

Gaskiyar ita ce Daraktan CBER Vinay Prasad ya mamaye masu kula da FDA wanda ya ba da shawarar cewa duk allurar rigakafin Covid guda uku a halin yanzu a ƙarƙashin EUA na tsaye a amince da su ga kowane rukunin shekaru, gami da yara masu lafiya. Wanne ya haifar da tambayar, me yasa har yanzu muna da Izinin Amfani da Gaggawa don waɗannan samfuran yayin da babu gaggawar likita a fili?

Dalilin da Prasad ya bayar game da wannan musun yakamata ya zama mai kwantar da hankali ga duk motsin 'yanci na likita. Yace cikin nasa wasiƙar gaskatawa:

• Shin akwai tabbataccen tabbataccen fa'idar aikin asibiti don yi wa yara masu lafiya allurar rigakafin mRNA? Ofishin Sadarwa, Watsawa da Ci Gaba (OCD) a cikin Cibiyar Nazarin Halittu da Bincike (CBER) amsar ita ce, a halin yanzu, tare da mafi kyawun bayanai, a'a.
• Moderna bai taɓa nuna raguwa a cikin mummunan Covid-19 ba, asibiti, zaman ICU, ko mutuwa a cikin binciken da bazuwar yara.
• Moderna bai nuna cewa rigakafin Covid-19 yana rage dogon Covid ko watsawa a kowane wuri a kowane zamani tare da bayanai masu inganci. Babu mai nema ko wani ɓangare na uku da aka nuna ƙarancin kwanakin makaranta da aka rasa tare da ingantaccen bayanai.
• Yi wa waɗannan mutane allurar rigakafi (masu lafiyayyen yara masu rigakafin halitta) yana ɗauke da rashin tabbas game da ko fa'idodin sun zarce kasada.
• Kodayake an ba da allurar rigakafin Covid-19 ga biliyoyin mutane kuma an yi nazari mai zurfi game da illolin, babu wanda ya san ko waɗannan samfuran suna da lahani waɗanda kawai suka wanzu shekaru 10 ko 20 bayan haka, saboda haka ƙayyadaddun lokaci ne. Jahilci ne a yi iƙirarin cewa haɗarin da ba a sani ba na dogon lokaci ba zai yiwu ba.
• Kwayoyin rigakafi ba ma'auni na zinari ba ne a kimiyya, kuma ba za a iya tabbatar da fa'idar fa'idar aikin asibiti ba kawai saboda an ƙara ƙwayoyin rigakafi. Magungunan rigakafi na iya ƙara ƙwayoyin rigakafi, amma sun kasa ƙara haɓaka sakamakon asibiti.
• Za a buƙaci gwaje-gwajen da aka bazu na auna sakamakon asibiti don amincewa da waɗannan samfuran ga mutane masu lafiya.
• A ƙarshe FDA tana da alhaki ga jama'ar Amurka, kuma Amurkawa sun faɗi da yawa cewa suna jin shaidar yin rigakafin rigakafi ga yaro mai lafiya tare da samfurin Covid-19 mRNA bai isa ya tilasta musu yin aiki ba. CBER OCD, bayan yin nazari a hankali na shaidar kimiyya, ya yarda da yawancin Amurkawa.

Da yake magana da kaina a matsayin masanin kimiyyar likita tare da ƙwarewa ta musamman a wannan yanki, na yarda da duk waɗannan batutuwa.

Kuma wannan ya zo a kan diddigin Kwamishinan FDA Makary gaya wa Epoch Times cewa shi, "da kaina ya san mutanen da allurar ta ji rauni. Ni da kaina na san abokai da suka rasa ƙaunataccena daga rigakafin mRNA COVID."

Ya yi magana da masu sukar wadanda suka ce shi da Kennedy ba sa yin isasshen alluran rigakafin Covid-19, "Don haka mutane suna da 'yancin yin fushi. An yaudare su ta fuskoki daban-daban na cutar ta COVID-XNUMX. An umarce su da su shiga cikin layin rigakafin ko da suna da lafiya da ƙarancin haɗari kuma sun riga sun sami ƙwayoyin rigakafi. Mutane suna da 'yancin yin fushi, amma zan nemi mutane su yi haƙuri tare da mu kamar yadda muka yi ta hanyar kimiyya.

Abubuwa suna tafiya daidai. Sakatare Kennedy koyaushe yana cewa dole ne mu mayar da ilimin taurarin gwal zuwa HHS. Lokacin da bayanan suka fita kuma shawarwarin sun kasance, Ina da cikakken kwarin gwiwa cewa zai motsa daidai. 

Kuna tsammanin duk wani FDA da ta gabata zai ƙi amincewa da duk wani alluran rigakafi, balle maganin Covid-19? Shaidun sun nuna akasin haka. Wannan babban ci gaba ne.

Ba ni da wani tasiri ko iko akan abin da aka yanke shawara a FDA. Sun yanke shawara, mai kyau ko mara kyau. Sakataren HHS ya yanke shawarar ba tare da haɗin kai ko ma sani ba. 

Yarjejeniya ta ACIP ta bayyana cewa yanzu ya rage ga ACIP don ba da shawarar daidaitaccen jagorar kulawa don amfani da wannan samfur ga Daraktan CDC. Kuma zai kasance ga Daraktan CDC don karɓa ko ƙin waɗannan shawarwarin. Waɗancan hujjoji ne na jama'a, don haka ina da 'yanci in faɗi su. Lokaci zai nuna yadda ACIP ke sauke wannan alhakin.

Kuma a'a, duk da abin da wasu wakilan rikice-rikicen rikice-rikice suka yi iƙirari, har zuwa yau, sabuwar ACIP ba ta zaɓi don tallafawa ko ba ta goyi bayan duk shawarwarin samfuran rigakafin Covid-19 ba.

Ga masu sha'awar ƙarin karatu, Ina ba da shawarar bugu mai zuwa. Marubucin farko na wannan aikin ɗan'uwan ACIP ne kuma MIT Cikakken Farfesa wanda nake girmamawa sosai. Babban marubucin shine Babban Likitan Surgeon na Florida, wanda kuma nake matukar girmamawa gareshi. mRNA-1273 = Spikevax, kuma wannan bayanan yana goyan bayan hakan, idan Daraktan CBER Prasad ya yi imanin cewa ya zama dole a amince da aƙalla samfurin mRNA Covid-19 don kare manyan haɗari na iyaye waɗanda ke buƙatar samun samfurin mRNA Covid-19 na ɗansu, Spikevax zaɓi ne mai ma'ana. Wannan shi ne kiran da ya yi, kuma ya yi shi, na alheri ko mara kyau.

A cikin al'umma ta al'ada kuma mai adalci, wannan rubutun zai riga ya kammala bitar takwarorinsu kuma an buga shi a cikin babban mujallar binciken likita. Gaskiyar cewa bai nuna cewa farfaganda, ba da izini, da PsyWar game da samfuran Covid-19 mRNA na ci gaba.

Watanni Goma Sha Biyu Duk Dalilin Mutuwar Bayan Farko COVID-19 Alurar riga kafi tare da Pfizer-BioNTech ko mRNA-1273 tsakanin Manya da ke zaune a Florida

Farashin Levi, Fahad Mansuri, Melissa M. Jordan, Joseph A. Ladapo

Abstract

Manufa Don bincika tasirin tasirin jerin farko na manzo RNA (mRNA) BNT162b2 (Pfizer) da mRNA-1273 (Moderna) akan kowane dalili da mutuwar COVID-19 tsakanin mazauna Florida.

Design Ƙungiya mai daidaitawa tare da ƙididdigar ƙima da daidaitacce na haɗari sama da watanni 12 masu biyo baya.

Kafa Bayanan bayanan lafiyar jama'a na matakin jihar Florida tare da bayanai game da rigakafin COVID-19, halayen zamantakewar alurar riga kafi, wurin da ake yin rigakafin, da ƙididdiga masu mahimmanci.

Wanda su ka Halarta Ƙungiyoyin da suka dace na 1,470,100 balagaggu balagaggu mazauna Florida waɗanda ke karɓar aƙalla allurai biyu, ƙasa da makonni shida baya, na ko dai maganin BNT162b2 ko mRNA-1273 mRNA tsakanin 18 ga Disamba, 2020, da Agusta 31, 2021.

Tsakani Maganin farko tare da allurai biyu na ko dai BNT162b2 ko mRNA-1273

Tsarin mahimman bayanai Dalilin duka, cututtukan zuciya, COVID-19, da marasa COVID-19 mace-mace a cikin watanni 12 bayan kashi na biyu na rigakafin COVID-19

results Akwai 9,162,484 balagaggu balagaggu mazauna Florida waɗanda suka cika sharuddan haɗawa, gami da masu karɓar rigakafin BNT5,328,226b162 2 da masu karɓar rigakafin mRNA-3,834,258 1273. An daidaita jimillar alluran rigakafi 1,470,100 1-to-1 bisa ka'idoji bakwai, gami da tsarin kidayar jama'a. Idan aka kwatanta da masu karɓa na mRNA-1273, masu karɓa na BNT162b2 suna da haɗari mafi girma ga duk abin da ke haifar da mace-mace (847.2 vs. 617.9 mutuwar da 100,000; rashin daidaituwa, OR [95% CI]: 1.384 [1.331, cardiovascular mootality), 1.439. Mutuwar 248.7 a cikin mutane 162.4 KO [100,000% CI]: 95 [1.540, 1.431]), mace-macen COVID-1.657 (19 vs. 55.5 mutuwar a cikin mutane 29.5; KO [100,000% CI]: 95; mace-mace marasa COVID-1.882 (1.596 vs. 2.220 mutuwar a cikin mutane 19; KO [791.6% CI]: 588.4 [100,000, 95]). Sakamakon sarrafawa mara kyau bai nuna wata alama ta ma'anar ruɗani da ba a lura da ita ba.

Kammalawa Manya na Florida waɗanda suka karɓi BNT162b2 suna da haɗarin haɗari mafi girma na tsawon watanni 12, cututtukan zuciya, COVID-19, da mace-mace marasa COVID-19 idan aka kwatanta da masu karɓar mRNA-1273. Waɗannan binciken suna ba da shawara na bambance-bambancen marasa takamaiman tasirin BNT162b2 da mRNA-1273 COVID-19, da yuwuwar tasirin illa akan kowane dalili da mace-mace na zuciya. Suna jaddada buƙatar kimanta alluran rigakafin ta amfani da wuraren ƙarshen asibiti waɗanda suka wuce cututtukan da aka yi niyya.

Abin da aka riga aka sani akan wannan batu

• Alurar riga kafi na iya samun tasirin kiwon lafiya fiye da cututtukan da suka yi niyya, gami da yuwuwar illolin da ke haifar da mace-mace.
• Tasirin dangi na jerin farkon manzo RNA (mRNA) BNT162b2 (Pfizer) da mRNA-1273 (Moderna) akan duk-mutuwar da ba COVID-19 ba ba a yi nazari sosai ba.

Abin da wannan batu ya ƙara

• Manya na Florida waɗanda suka karɓi BNT162b2 suna da haɗarin haɗari mafi girma na tsawon watanni 12, cututtukan zuciya, COVID-19, da mace-mace marasa COVID-19 idan aka kwatanta da masu karɓar mRNA-1273 a hankali.
• Waɗannan binciken suna ba da shawara na bambance-bambancen marasa takamaiman tasirin BNT162b2 da mRNA-1273 COVID-19, da yuwuwar tasirin illa akan kowane dalili da mace-mace na zuciya.

Gasar Bayanin Sha'awa

MJ, FM, da JL sun sami goyan bayan Ma'aikatar Lafiya ta Florida kuma JL tana aiki a matsayin Babban Likitan Jiha; RL yana da alakar kuɗi tare da Bluebell Foundation/Chicago Community Trust; babu wasu alaƙa ko ayyukan da za su iya bayyana sun yi tasiri ga aikin da aka ƙaddamar.

Bayanin Kudin Kuɗi

Binciken bai sami wani tallafi na waje ba.

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