"Kokarin sarrafa ƙwayoyin cuta na numfashi na mucosal tare da tsarin rigakafi da ba a sake yin amfani da su ba ya zuwa yanzu bai yi nasara ba." Dr A Fauci (tsohon daraktan NIAID), 2023, yayi tsokaci kan allurar rigakafin Covid-19.
Jaridar Mai watsa shiri na Cell & Microbe kwanan nan aka buga daya daga cikin mafi mahimmanci Takardu na zamanin Covid; 'Sake Tunanin rigakafi na gaba don coronaviruses, ƙwayoyin mura, da sauran ƙwayoyin cuta na numfashi.' Wannan ya haifar da 'yan ban mamaki idan aka yi la'akari da mawallafinsa da abubuwan da ke ciki.
Na farko, marubucin ƙarshe shine Dr. Anthony Fauci, darekta mai ritaya kwanan nan na Cibiyar Kula da Cututtuka da Cututtuka ta Amurka (NIAID), wanda ya zama mai magana da yawun kafofin watsa labarai. Na biyu, saboda Dr. Fauci da abokan aikinsa sun ba da shaida cewa yawancin abin da masu iko suka gaya wa jama'a game da rigakafin Covid ya saba wa abin da suka san gaskiya ne.
Godiya ga Dr. Fauci saboda zuwan tsabta akan tushen ƙwayoyin cuta da rigakafi. Idan manyan jaridun likita irin su New England Journal of Medicine ko Lancet sun yi aiki da editoci masu irin wannan ilimin shekaru uku da suka wuce, da sun ba da gudummawa ga lafiyar jama'a maimakon rugujewar al'umma da yancin ɗan adam na duniya. Idan da masu mulki sun bayyana waɗannan gaskiyar kuma sun kafa manufofinsu a kansu, da abubuwa ma sun bambanta.
Hakazalika ga duka cibiyar kiwon lafiya. Kila an guje wa mutuwa da yawa, talauci da rashin daidaito. Wataƙila kuma an kiyaye aminci a cikin cibiyoyin da suke aiki a ciki.
Takardar da Dr. Fauci ya rubuta tare ta tattauna yuwuwar samar da alluran rigakafin cutar coronavirus da alluran rigakafi ga sauran ƙwayoyin cuta masu saurin canzawa na numfashi. Zai fi dacewa ta shiga cikin takarda a sassa uku; yin bitar shaidun da marubutan suka bayar, tare da lura da ragowar akidar da ke ci gaba da wanzuwa duk da cewa ta saba wa wannan shaidar, kuma a ƙarshe la'akari da tasirin takarda game da martanin lafiyar jama'a na Covid.
Karatun asali takarda ana ba da shawarar, kamar yadda wannan labarin ke ba da ƙarin haske kawai.
- Rashin ingancin maganin rigakafi da fifikon rigakafi na halitta.
Binciken ya bayyana karara cewa alluran rigakafin ƙwayoyin cuta na numfashi kamar mura ko coronaviruses (misali SARS-CoV-2 da ke da alhakin Covid) ba su da yuwuwar cimma matakan tasirin da muke tsammani daga sauran alluran rigakafin. Marubutan sun lura Bayanan CDC nuna allurar rigakafin mura, wanda yanzu ake turawa ga duk shekaru daga watanni 6 zuwa sama, suna da inganci daga kashi 14 cikin ɗari zuwa matsakaicin kashi 60 cikin ɗari tun daga 2005 (wanda aka tsawaita shekaru 17 zai ragu da wannan zuwa kashi 10 cikin ɗari, tare da matsakaicin tasirin rigakafin (VE) a ƙasa da kashi 40 kawai). Kamar yadda Dr Fauci ya lura:
"...Mafi kyawun allurar rigakafin mura ba za su isa ba don lasisi ga yawancin cututtukan da za a iya rigakafin rigakafi. "
Tabbas:
"...Ba abin mamaki ba ne cewa babu ɗayan ƙwayoyin cuta na numfashi na mucosal da aka taɓa samun kulawa da kyau ta hanyar alluran rigakafi.. "
Marubutan sun ba da cikakkun bayanai game da wannan rashin ingancin:
"Alurar rigakafin waɗannan ƙwayoyin cuta guda biyu daban-daban suna da halaye gama gari: suna ba da kariya marar cikawa da ɗan gajeren lokaci daga bambance-bambancen ƙwayoyin cuta waɗanda ke guje wa rigakafin yawan jama'a.. "
Ba kawai yawan maye gurbi ne ke da matsala ba, har ma da yanayin kamuwa da cuta:
"Suna yin kwafi da yawa a cikin nama na mucosal na gida, ba tare da haifar da viremia ba, kuma ba sa haɗuwa da tsarin tsarin rigakafi ko cikakken ƙarfin amsawar rigakafi, wanda ke ɗaukar aƙalla kwanaki 5-7 don girma, yawanci da kyau bayan kololuwar kwafi da ci gaba da watsawa ga wasu.. "
Kamar yadda wannan bayanin kima na gaskiya, ba a taɓa tsammanin allurar rigakafin Covid za su iya rage kamuwa da cuta ko yadawa ba.
Marubutan sun bayyana abin da yawancin likitocin cututtukan cututtuka da masu ilimin rigakafi suka sani a duk lokacin barkewar cutar ta Covid; cewa ƙwayoyin rigakafi masu yawo (IgG da IgM) suna taka iyakataccen rawa wajen sarrafa cututtuka kamar Covid, yayin da ƙwayoyin rigakafi na mucosal (IgA) a cikin rufin sashin numfashi na sama, ba a motsa su ta hanyar allurar rigakafi ba, suna taka rawar da ta fi girma:
"Muhimmancin sirrin mucosal IgA (sIgA) a cikin takamaiman martani na ƙwayoyin cuta game da cututtukan ƙwayoyin cuta na numfashi an daɗe ana yaba da ƙwayoyin mura, RSV da kuma kwanan nan SARS-CoV-2.. "
Muhimmancin a nan shi ne cewa tsarin rigakafi, kamar yadda mawallafa suka lura, ba su haifar da samar da mucosal IgA ba.
Ingancin tasirin Covid mai tsanani wanda allurar rigakafi ke bayarwa ga wasu mutanen da ba a fallasa su a cikin wata tagar da abin lura ya yi bayaninsa:
"IgA ya bayyana ya zama mafi kyawun tasiri a cikin sashin numfashi na sama, yayin da IgG ya fi kyau a cikin huhu. "
Bambance-bambancen farko na SARS-CoV-2 suna da alaƙa da shigar huhu. Yayin da CDC ta nuna cewa allurar rigakafi a saman rigakafi na halitta yana ba da kusan babu ƙarin fa'ida ta asibiti, raguwar mace-mace na Covid (kamar yadda ya bambanta da mace-mace duka) da ake da'awar alluran rigakafin tsakanin farkon yuwuwar. hana rigakafi kuma daga baya raguwa of inganci yana da madaidaicin tushen rigakafi.
Kamar yadda NIH ta amince, T-kwayoyin suma babban kariya ne daga coronaviruses, tare da rigakafin giciye daga SARS-CoV-2 da aka gani a cikin mutane da yawa waɗanda ba su kamu da cutar a baya ba. Fauci et al. Yi lura mai ban sha'awa cewa T-cell yana daidaitawa don rigakafi ana samun su bayan kamuwa da mura, amma ba bayan rigakafin mura ba. Wannan yana nuna ƙarin hanyar don bayyana ƙarancin ingancin alluran rigakafin idan aka kwatanta da kamuwa da cuta na halitta, ko da a gaba farkon SARS-CoV-2 bambance-bambancen.
A taƙaice, duka allurar rigakafin coronavirus da mura ba su da kyau:
"Ayyukan rigakafin waɗannan ƙwayoyin cuta guda biyu daban-daban suna da halaye gama gari: suna ba da kariya marar cikawa da ɗan gajeren lokaci daga bambance-bambancen ƙwayoyin cuta waɗanda ke guje wa rigakafin yawan jama'a."
A bayyane, kuma a takaice sanya.
Yin gwagwarmaya da akidar
Haƙiƙanin ƙimar takarda ita ce ta hanyar da ta bambanta aƙidar Covid da shaida. Marubutan sun fara da lura cewa kusan mutane miliyan 5 galibi suna mutuwa a duk duniya a duk shekara daga ƙwayoyin cuta na numfashi. Kwatanta da Hukumar Lafiya ta Duniya 6.8 miliyan mutuwar Covid rubuce sama da shekaru uku zai samar da mahallin mai amfani (Lura: yana da mahimmanci a rarrabe mace-mace daga Covid daga jimlar mutuwar daga cutar da ta haɗa da waɗanda ke da tasirin Covid da kullewa). Duk da haka, irin wannan amincewar ba zai yi daidai da maganganunsu mai zuwa cewa:
"SARS-CoV-2 ta kashe mutane sama da miliyan 1 a Amurka. "
Wannan, ba shakka, ƙarya ne. Ya dogara ne akan mace-mace bayan ingantaccen sakamakon PCR na kwanan nan, tare da manazarcin CNN na Covid yanzu shigar da exggerations hannu. Abin ban mamaki, marubutan sun ce:
"...saurin haɓakawa da tura alluran rigakafin SARS-CoV-2 sun ceci rayuka marasa adadi kuma sun taimaka wajen cimma nasarar shawo kan cutar ta farko."
Cewa alluran sun bayyana sun ceci rayuka da yawa don marubutan suyi tunani abin mamaki ne. Dr. Fauci ya ji yana iya yin la'akari da adadin wadanda suka mutu a cikin shekarar farko ta barkewar Covid lokacin da kwayar cutar ta kama mutanen da aka ce ba su da riga-kafi. Yawan mace-mace da aka yi rikodin ya kasance iri ɗaya a cikin shekara ta biyu, bayan da aka ba da allurar rigakafin cutar, duk da mummunar cutar da ta ta'allaka sosai a cikin ƙaramin ƙanƙara, ingantaccen tsari. tsirarun tsofaffi wanda shirin rigakafin ya ba da fifiko. Don haka ya fi dacewa cewa allurar rigakafin sun kawar da mutuwar mutane kaɗan. Irin wannan rashin tasiri ya dace daidai da tsammanin mawallafin da aka ambata a sama.
Samun "kamuwa da cutar ta farko" baƙon abu ne kawai ga marubutan da suka lura cewa amsawar IgG ba ta shiga cikin gaske har sai bayan kololuwar ƙwayar cuta da watsawa. Haɓaka aƙidar ƙarya da shaida yana da wuyar gaske lokacin da kuka ɗora sunan ku akan akidar, don haka gwagwarmayar da ke bayyana a nan abu ne mai fahimta.
Dangane da tasirin gaskiya akan shirin rigakafin na Covid, zamu iya karɓar amincewar da ba ta dace ba cewa duk da rigakafin:
"...adadi mai yawa na mace-mace [daga cikin wadanda aka yi wa allurar] har yanzu suna faruwa. "
Kamar yadda marubutan suka gane:
"Ƙoƙarin sarrafa ƙwayoyin cuta na numfashi na mucosal tare da tsarin rigakafi da ba a sake maimaitawa ba ya zuwa yanzu bai yi nasara ba.. "
Muhimmancin wannan takarda
Marubutan wannan takarda ba sa haɓaka sabbin zato don bayyana dalilin da yasa aikin rigakafin Covid ya kasance abin takaici. Suna kawai sake maimaita ilimin baya. Hasashen inganci da dorewar ingancin alluran rigakafi, da allurar rigakafin da ke ba da 'hanyar fita daga cutar,' ba a sa ran za su zama gaskiya ba. Waɗannan ikirari wata dabara ce ta ƙarfafa riƙon shirin da zai arzuta wasu ƴan kasuwa da masu kula da lafiyar jama'a. Mutanen da ke da ilimin da ya dace game da batun sun san maganganun ba daidai ba ne, kodayake kaɗan ne suka faɗi haka. Sauran, mai yiwuwa, an yaudare su.
Fauci da mawallafa don haka suna ba da muhimmiyar gudummawa ga labarin Covid, suna jadada yaudarar shekaru biyu da suka gabata. Da'awar cewa wannan yaudarar ta inganta gabaɗaya - cewa an sami 'cututtukan duniya' kuma yarda da allurar rigakafin zai kasance don amfanin jama'a - Fauci ya musanta. et alshaida. Alurar rigakafin jama'a, yayin da yake samun nasara sosai ta fannin kuɗi ga ƙananan ƴan tsiraru amma masu tasiri, ba a taɓa tsammanin yin aiki ba.
Kariya na halitta koyaushe zai kasance mafi inganci fiye da alluran rigakafi, da maganganun akasin haka kamar su John Snow Memorandum inganta ta Lancet saba fahimtar ƙwararru da hankali. Wulakanta waɗanda ke nuni da fifikon kariyar dabi'a shi ne zagi. Lokacin da marubucin ƙarshe na wannan takarda ya bayyana a bainar jama'a cewa allurar rigakafin Covid-19 suna aiki da kyau fiye da rigakafi na halitta don kare ku daga coronavirus, ya san hakan ba zai yiwu ya zama gaskiya ba.
Ƙungiyar kula da lafiyar jama'a ta yaudari jama'a don inganta alluran da sabon nau'in magunguna. Ba su da bayanan aminci na dogon lokaci, alluran rigakafin sun yi niyya ga wata ƙwayar cuta da suka san ba ta da wata illa ga yawancin waɗanda suke magana da su, yayin da da yawa ko mafi yawan sun riga sun sami ingantaccen rigakafi na halitta.
Sakamakon dogon lokaci na wannan yaudara har yanzu ba a buga ba, kuma zai haɗa da asarar amincewa ga lafiyar jama'a da aikin likitanci. Wannan ya dace, kuma ana iya jayayya cewa abu ne mai kyau. Yadda kowane mutum zai yi don tabbatar da cewa waɗanda suka tallata wannan labari sun yaudare su, zaɓi ne na mutum ɗaya.
Mafi wauta za a yi shi ne a yi riya cewa yaudarar ba ta faru ba.
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David Bell, Babban Masanin Kimiyya a Cibiyar Brownstone, likitan lafiyar jama'a ne kuma mai ba da shawara kan ilimin halittu a cikin lafiyar duniya. David tsohon jami'in kiwon lafiya ne kuma masanin kimiyya a Hukumar Lafiya ta Duniya (WHO), Shugaban Shirin Malaria da cututtukan zazzabi a Gidauniyar Innovative New Diagnostics (FIND) a Geneva, Switzerland, kuma Daraktan Fasahar Kiwon Lafiya ta Duniya a Asusun Kula da Lafiya na Duniya na Intellectual Ventures a Bellevue, WA, Amurka.
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