Cibiyar CDC shafin bayani akan alluran rigakafin Covid-19 sun ƙunshi abubuwan harsashi masu zuwa akan "Yadda mRNA COVID-19 alluran ke aiki:"
Na farko, ana ba da allurar mRNA COVID-19 a cikin tsokar hannu ta sama ko cinya ta sama, ya danganta da shekarun wanda ke yin rigakafin.
Bayan alurar riga kafi, mRNA zai shiga cikin ƙwayoyin tsoka. Da zarar sun shiga, suna amfani da injin sel don samar da wani yanki mara lahani na abin da ake kira furotin mai karu…. Bayan an yi guntun furotin, ƙwayoyin mu suna rushe mRNA kuma su cire shi, suna barin jiki a matsayin sharar gida.
Ko, a wasu kalmomi, kamar yadda aka daɗe ana gaya mana, "shi" - mRNA - "yana zaune a hannu." Sannan, bayan an umurci ƙwayoyin tsoka don samar da karu, an zubar da su.
Amma duba hoton da ke ƙasa daga gabatarwar kwanan nan kan rigakafin mRNA a Majalisar Tarayyar Turai. Hoton ya kasance buga a kan Twitter da Virginie Joron 'yar majalisar dokokin Faransa. Mai magana ba ƙaramin iko bane fiye da Özlem Türeci, Babban Jami'in Kiwon Lafiya na BioNTech: kamfanin fasahar kere-kere na Jamus wanda ya haɓaka abin da ya zama sananne ga yawancin duniya a matsayin rigakafin "Pfizer" Covid-19.
Ku dubi faifan Türeci, wanda ke ba da labari daban-daban fiye da wanda CDC ke gaya wa Amurkawa shekaru biyu da suka gabata.
Nisa daga "tsayawa a hannu" da shigar da ƙwayoyin tsoka a wurin allurar, wurin allurar shine kawai wurin tashi don tafiya wanda yakamata ya ɗauki mRNA maimakon zuwa ƙwayoyin lymph. Babban taken nunin shine "Kawo mRNA zuwa sel masu dacewa a wuraren da suka dace." Deltoid ba shine wurin da ya dace ba; Lymph nodes ne.
Da zarar a cikin nodes na lymph, takamaiman nau'in tantanin halitta, sel dendritic, yakamata su kera furotin mai karu: anan an siffanta shi da launi a matsayin "hoton da ake so" wanda zai taimaka tsarin rigakafi don gano kwayar cutar SARS-CoV-2 a yanayin bayyanar cutar ta gaba.
A safiya daga Alurar rigakafin, Littafin da Türeci da mijinta, BioNTech Shugaba Ugur Sahin, suka rubuta tare da dan jarida Joe Miller, ya bayyana dalilin da ya sa BioNTech ta dandamali na musamman hari da lymph nodes:
Abin da Ugur ya koya shi ne cewa wurin da allurar rigakafi ta kai 'posttar da ake so' na da matukar muhimmanci. Dalilin wannan, ƙungiyar ma'auratan a Mainz daga baya sun gane, shine cewa ba duka ƙwayoyin dendritic ba… an halicce su daidai. Wadanda ke zaune a cikin nodes na lymph - wanda saifa ya fi girma - sun ƙware musamman wajen ɗaukar mRNA da tabbatar da an yi aiki da umarnin da yake ɗauka. Wadannan gabobi masu siffar koda, da ake samu a karkashin rungumar mu, a cikin makwancinmu, da kuma wasu wurare da dama a cikin jiki, su ne wuraren da ke tattare da tsarin garkuwar jiki. (shafi na 98)
Tabbas, Sahin da Türeci sun ƙudiri aniyar shigar da mRNA ɗinsu a cikin ƙwayoyin lymph har an yi musu allura na farko na mRNA. kai tsaye zuwa cikin nodes na Lymph nodes a cikin duri (shafi 104).
Ba lallai ba ne a faɗi, irin wannan hanyar ba ta yuwu a sami karɓuwa da yawa azaman maganin rigakafi! Wannan shine dalilin da ya sa ma'auratan, kamar yadda aka bayyana a cikin littafinsu, suna buƙatar tattara mRNA a cikin nau'in nanoparticles na lipid, don tabbatar da cewa mRNA da ake gudanarwa ta hanyar allurar ciki, duk da haka, za a yadu a jiki kuma ta haka ya isa ga ƙwayoyin lymph.
Wannan shine a faɗi cewa faɗin rarrabar halittun mRNA wanda ya fito haske bayan fiddawa bai taɓa zama kwaro ba. Yana da sifa na fasahar mRNA ta BioNTech. Bayan da aka ba da amsawar rigakafi ta hanyar allura a cikin makwancinta, Sahin ma an ce ya yi mamakin, "Yaya mahimmancin amsawar rigakafin zai kasance idan allurar rigakafi ta shiga cikin ƙwayoyin lymphatic a cikin jiki, kuma ta ɗauki duk mazaunin DCs [kwayoyin dendritic] a cikin aiki? (shafi na 105)
Don haka, me yasa CDC ke yin ƙarya game da wannan shekaru biyu da suka gabata kuma ta nace cewa mRNA "ya kasance a hannu?" Da kyau, amsar da ta dace ita ce ra'ayin zama na mRNA a wurin allurar yana da kwantar da hankali, tunda in ba haka ba muna iya jin tsoron illar tsarin daidaitaccen nau'in da ya bayyana tun lokacin da aka fitar.
Yana da kyau a lura, haka kuma, a cikin haɓaka maganinta, kamar yadda aka tattauna a cikin labarina na farko nan, BioNTech kawai ya tsallake abin da ake kira nazarin ilimin harhada magunguna na aminci wanda manufarsa ita ce daidai don gwada rigakafin ɗan takara don yuwuwar tasirin illa na tsarin - kuma masu gudanarwa, gami da FDA, bari kamfanin ya yi.
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Robert Kogon shi ne sunan alkalami na wani ɗan jarida da ake bugawa da yawa wanda ke yin rubuce-rubuce kan al'amuran Turai.
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